TY - JOUR
T1 - Stereotactic radiosurgery of cerebral arteriovenous malformations
T2 - Appearance of perinidal T2 hyperintensity signal as a predictor of favorable treatment response
AU - Mobin, Fardad
AU - De Salles, Antonio A F
AU - Abdelaziz, Osama
AU - Cabatan-Awang, Cynthia
AU - Solberg, Timothy
AU - Selch, Michael
PY - 2000/5
Y1 - 2000/5
N2 - The purpose of this study was to analyze the significance of perinidal T2 hyperintensity appearance after radiosurgery of arteriovenous malformations (AVMs), as a predictor of treatment response. Our initial experience with linear accelerator (LINAC) radiosurgery at University of California, Los Angeles, between 1990 and 1997 involved treatment of 129 patients affected by cerebral AVMs. Based upon availability of neuroimaging follow-up, 48 patients with 50 AVMs were selected for review. Forty (80%) of the AVMs underwent complete obliteration or significant reduction on follow-up MRI, on average 20 months after radiosurgery. Thirteen (72%) of 18 obliterated AVMs were associated with perinidal T2 hyperintensity signal, on average 18 months (6-49) after radiosurgery. Ten (20%) of 50 AVMs (average volume 23.1 cm3, ranging 7.5-46.5) were unchanged. Furthermore, only 3 AVMs in this group showed reversible T2 signal changes. In patients with complete nidal obliteration, appearance on T2 hyperintensity signal achieves 72% sensitivity in predicting successful treatment response. Copyright (C) 2000 S. Karger AG, Basel.
AB - The purpose of this study was to analyze the significance of perinidal T2 hyperintensity appearance after radiosurgery of arteriovenous malformations (AVMs), as a predictor of treatment response. Our initial experience with linear accelerator (LINAC) radiosurgery at University of California, Los Angeles, between 1990 and 1997 involved treatment of 129 patients affected by cerebral AVMs. Based upon availability of neuroimaging follow-up, 48 patients with 50 AVMs were selected for review. Forty (80%) of the AVMs underwent complete obliteration or significant reduction on follow-up MRI, on average 20 months after radiosurgery. Thirteen (72%) of 18 obliterated AVMs were associated with perinidal T2 hyperintensity signal, on average 18 months (6-49) after radiosurgery. Ten (20%) of 50 AVMs (average volume 23.1 cm3, ranging 7.5-46.5) were unchanged. Furthermore, only 3 AVMs in this group showed reversible T2 signal changes. In patients with complete nidal obliteration, appearance on T2 hyperintensity signal achieves 72% sensitivity in predicting successful treatment response. Copyright (C) 2000 S. Karger AG, Basel.
KW - Arteriovenous malformations
KW - Magnetic resonance imaging
KW - Stereotactic radiosurgery
KW - Stereotactic surgery
KW - Treatment response
UR - http://www.scopus.com/inward/record.url?scp=0343134135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0343134135&partnerID=8YFLogxK
U2 - 10.1159/000029751
DO - 10.1159/000029751
M3 - Article
C2 - 10853098
AN - SCOPUS:0343134135
SN - 1011-6125
VL - 73
SP - 50
EP - 59
JO - Stereotactic and Functional Neurosurgery
JF - Stereotactic and Functional Neurosurgery
IS - 1-4
ER -