Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

J. R. Falck; P. Srinagesh Kumar; Y. Krishna Reddy; Gang Zou; Jorge H. Capdevila

doi:10.1016/S0040-4039(01)01535-0

Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

J. R. Falck, P. Srinagesh Kumar, Y. Krishna Reddy, Gang Zou, Jorge H. Capdevila

Biochemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z),12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides.

Original language	English (US)
Pages (from-to)	7211-7212
Number of pages	2
Journal	Tetrahedron Letters
Volume	42
Issue number	41
DOIs	https://doi.org/10.1016/S0040-4039(01)01535-0
State	Published - Oct 8 2001

Keywords

Biologically active compounds
Eicosanoids
Lipids
Silver
Suzuki-Miyaura

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01535-0

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title = "Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling",

abstract = "Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z),12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides.",

keywords = "Biologically active compounds, Eicosanoids, Lipids, Silver, Suzuki-Miyaura",

author = "Falck, {J. R.} and Kumar, {P. Srinagesh} and Reddy, {Y. Krishna} and Gang Zou and Capdevila, {Jorge H.}",

note = "Funding Information: Financial support provided by the Robert A. Welch Foundation, NIH (GM 31278, DK 38226) and an unrestricted grant from Taisho Pharmaceutical Co., Ltd. ",

year = "2001",

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doi = "10.1016/S0040-4039(01)01535-0",

language = "English (US)",

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T1 - Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

AU - Falck, J. R.

AU - Kumar, P. Srinagesh

AU - Reddy, Y. Krishna

AU - Zou, Gang

AU - Capdevila, Jorge H.

N1 - Funding Information: Financial support provided by the Robert A. Welch Foundation, NIH (GM 31278, DK 38226) and an unrestricted grant from Taisho Pharmaceutical Co., Ltd.

PY - 2001/10/8

Y1 - 2001/10/8

N2 - Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z),12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides.

AB - Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z),12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides.

KW - Biologically active compounds

KW - Eicosanoids

KW - Lipids

KW - Silver

KW - Suzuki-Miyaura

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M3 - Article

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EP - 7212

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

ER -

Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

Abstract

Keywords

ASJC Scopus subject areas

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