Abstract
The first stereoselective synthesis of Certonardolsterol D3 was described. Ene reaction and improved allylic oxidation were employed as key steps for efficient construction of the desired 3β,6α,15β-triol steroidal framework. The chiral side chain in Certonardolsterol D3 was finally introduced by Julia olefination.
Original language | English (US) |
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Pages (from-to) | 9738-9744 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 41 |
DOIs | |
State | Published - Oct 6 2008 |
Keywords
- Certonardolsterol
- Ene reaction
- Julia olefination
- Polyhydroxysterol
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry