Abstract
A stereocontrolled synthesis of α-amino-α′-alkoxy ketones is described. This pH-neutral copper(I) thiophene-2-carboxylate (CuTC)-catalyzed cross-coupling of amino acid thiol esters and chiral nonracemic α-alkoxyalkylstannanes gives α-amino-α′-alkoxy ketones in good to excellent yields with complete retention of configuration at the α-amino- and α-alkoxy-substituted stereocenters.
Original language | English (US) |
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Pages (from-to) | 3682-3685 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry