Abstract
Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.
Original language | English (US) |
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Pages (from-to) | 157-175 |
Number of pages | 19 |
Journal | Transgenic Research |
Volume | 10 |
Issue number | 2 |
DOIs | |
State | Published - 2001 |
Keywords
- 129S6/SvEvTac
- Behavior
- C57BL/6J
- Sample size
- Test battery
ASJC Scopus subject areas
- Biotechnology
- Animal Science and Zoology
- Genetics
- Agronomy and Crop Science