State-of-the-art materials for ultrasound-triggered drug delivery

Shashank R. Sirsi, Mark A. Borden

Research output: Contribution to journalReview articlepeer-review

349 Scopus citations


Ultrasound is a unique and exciting theranostic modality that can be used to track drug carriers, trigger drug release and improve drug deposition with high spatial precision. In this review, we briefly describe the mechanisms of interaction between drug carriers and ultrasound waves, including cavitation, streaming and hyperthermia, and how those interactions can promote drug release and tissue uptake. We then discuss the rational design of some state-of-the-art materials for ultrasound-triggered drug delivery and review recent progress for each drug carrier, focusing on the delivery of chemotherapeutic agents such as doxorubicin. These materials include nanocarrier formulations, such as liposomes and micelles, designed specifically for ultrasound-triggered drug release, as well as microbubbles, microbubble-nanocarrier hybrids, microbubble-seeded hydrogels and phase-change agents.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalAdvanced Drug Delivery Reviews
StatePublished - Jun 15 2014


  • Liposomes
  • Micelles
  • Microbubbles
  • Phase-change agents
  • Targeted drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science


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