Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma: Consensus Statement of the PRECEDE Consortium

the PRECEDE Consortium

doi:10.2214/AJR.22.27859

Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma: Consensus Statement of the PRECEDE Consortium

the PRECEDE Consortium

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a dismal survival rate. Screening the general population for early detection of PDAC is not recommended, but because early detection improves survival, high-risk individuals, defined as those meeting criteria based on a family history of PDAC and/or the presence of known pathogenic germline variant genes with PDAC risk, are recommended to undergo screening with MRI and/or endoscopic ultrasound at regular intervals. The Pancreatic Cancer Early Detection (PRECEDE) Consortium was formed in 2018 and is composed of gastroenterologists, geneticists, pancreatic surgeons, radiologists, statisticians, and researchers from 40 sites in North America, Europe, and Asia. The overarching goal of the PRECEDE Consortium is to facilitate earlier diagnosis of PDAC for high-risk individuals to increase survival of the disease. A standardized MRI protocol and reporting template are needed to enhance the quality of screening examinations, improve consistency of clinical management, and facilitate multiinstitutional research. We present a consensus statement to standardize MRI screening and reporting for individuals with elevated risk of pancreatic cancer.

Original language	English (US)
Pages (from-to)	903-914
Number of pages	12
Journal	American Journal of Roentgenology
Volume	219
Issue number	6
DOIs	https://doi.org/10.2214/AJR.22.27859
State	Published - Dec 2022

Keywords

HRI
MRI
PDAC
PRECEDE
Pancreatic Cancer Early Detection Consortium
high-risk individual
pancreatic ductal adenocarcinoma
reporting template
screening

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.22.27859

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@article{56d54cce50864bbd8b54fb95dae1c8f2,

title = "Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma: Consensus Statement of the PRECEDE Consortium",

abstract = "Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a dismal survival rate. Screening the general population for early detection of PDAC is not recommended, but because early detection improves survival, high-risk individuals, defined as those meeting criteria based on a family history of PDAC and/or the presence of known pathogenic germline variant genes with PDAC risk, are recommended to undergo screening with MRI and/or endoscopic ultrasound at regular intervals. The Pancreatic Cancer Early Detection (PRECEDE) Consortium was formed in 2018 and is composed of gastroenterologists, geneticists, pancreatic surgeons, radiologists, statisticians, and researchers from 40 sites in North America, Europe, and Asia. The overarching goal of the PRECEDE Consortium is to facilitate earlier diagnosis of PDAC for high-risk individuals to increase survival of the disease. A standardized MRI protocol and reporting template are needed to enhance the quality of screening examinations, improve consistency of clinical management, and facilitate multiinstitutional research. We present a consensus statement to standardize MRI screening and reporting for individuals with elevated risk of pancreatic cancer.",

keywords = "HRI, MRI, PDAC, PRECEDE, Pancreatic Cancer Early Detection Consortium, high-risk individual, pancreatic ductal adenocarcinoma, reporting template, screening",

author = "{the PRECEDE Consortium} and Chenchan Huang and Simeone, {Diane M.} and Lyndon Luk and Hecht, {Elizabeth M.} and Gaurav Khatri and Avinash Kambadakone and Hersh Chandarana and Ream, {Justin M.} and Everett, {Jessica N.} and Alexander Guimaraes and Joy Liau and Dasyam, {Anil K.} and Carla Harmath and Megibow, {Alec J.} and Salvatore Paiella and Kasmintan Schrader and Srinivas Gaddam and Fay Kastrinos and Joanne Jeter and Raymond Wadlow and Daniel Chung and Michael Wallace and Yan Bi and George Zogopoulos and Jennifer Permuth and Aimee Lucas and Aaron Grossberg and Rosalie Sears and Julie Earl and Talia Golan and Andrew Lowy and Sonia Kupfer and James Lindberg and Daniel Sussman and Nipun Merchant and Richard Kwon and Kelsey Klute and Bryson Katona and Randy Brand and Vivek Kaul and Teresa Brentnall and James Farrell",

note = "Publisher Copyright: {\textcopyright} American Roentgen Ray Society.",

year = "2022",

month = dec,

doi = "10.2214/AJR.22.27859",

language = "English (US)",

volume = "219",

pages = "903--914",

journal = "American Journal of Roentgenology",

issn = "0361-803X",

publisher = "American Roentgen Ray Society",

number = "6",

}

TY - JOUR

T1 - Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma

T2 - Consensus Statement of the PRECEDE Consortium

AU - the PRECEDE Consortium

AU - Huang, Chenchan

AU - Simeone, Diane M.

AU - Luk, Lyndon

AU - Hecht, Elizabeth M.

AU - Khatri, Gaurav

AU - Kambadakone, Avinash

AU - Chandarana, Hersh

AU - Ream, Justin M.

AU - Everett, Jessica N.

AU - Guimaraes, Alexander

AU - Liau, Joy

AU - Dasyam, Anil K.

AU - Harmath, Carla

AU - Megibow, Alec J.

AU - Paiella, Salvatore

AU - Schrader, Kasmintan

AU - Gaddam, Srinivas

AU - Kastrinos, Fay

AU - Jeter, Joanne

AU - Wadlow, Raymond

AU - Chung, Daniel

AU - Wallace, Michael

AU - Bi, Yan

AU - Zogopoulos, George

AU - Permuth, Jennifer

AU - Lucas, Aimee

AU - Grossberg, Aaron

AU - Sears, Rosalie

AU - Earl, Julie

AU - Golan, Talia

AU - Lowy, Andrew

AU - Kupfer, Sonia

AU - Lindberg, James

AU - Sussman, Daniel

AU - Merchant, Nipun

AU - Kwon, Richard

AU - Klute, Kelsey

AU - Katona, Bryson

AU - Brand, Randy

AU - Kaul, Vivek

AU - Brentnall, Teresa

AU - Farrell, James

PY - 2022/12

Y1 - 2022/12

N2 - Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a dismal survival rate. Screening the general population for early detection of PDAC is not recommended, but because early detection improves survival, high-risk individuals, defined as those meeting criteria based on a family history of PDAC and/or the presence of known pathogenic germline variant genes with PDAC risk, are recommended to undergo screening with MRI and/or endoscopic ultrasound at regular intervals. The Pancreatic Cancer Early Detection (PRECEDE) Consortium was formed in 2018 and is composed of gastroenterologists, geneticists, pancreatic surgeons, radiologists, statisticians, and researchers from 40 sites in North America, Europe, and Asia. The overarching goal of the PRECEDE Consortium is to facilitate earlier diagnosis of PDAC for high-risk individuals to increase survival of the disease. A standardized MRI protocol and reporting template are needed to enhance the quality of screening examinations, improve consistency of clinical management, and facilitate multiinstitutional research. We present a consensus statement to standardize MRI screening and reporting for individuals with elevated risk of pancreatic cancer.

AB - Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a dismal survival rate. Screening the general population for early detection of PDAC is not recommended, but because early detection improves survival, high-risk individuals, defined as those meeting criteria based on a family history of PDAC and/or the presence of known pathogenic germline variant genes with PDAC risk, are recommended to undergo screening with MRI and/or endoscopic ultrasound at regular intervals. The Pancreatic Cancer Early Detection (PRECEDE) Consortium was formed in 2018 and is composed of gastroenterologists, geneticists, pancreatic surgeons, radiologists, statisticians, and researchers from 40 sites in North America, Europe, and Asia. The overarching goal of the PRECEDE Consortium is to facilitate earlier diagnosis of PDAC for high-risk individuals to increase survival of the disease. A standardized MRI protocol and reporting template are needed to enhance the quality of screening examinations, improve consistency of clinical management, and facilitate multiinstitutional research. We present a consensus statement to standardize MRI screening and reporting for individuals with elevated risk of pancreatic cancer.

KW - HRI

KW - MRI

KW - PDAC

KW - PRECEDE

KW - Pancreatic Cancer Early Detection Consortium

KW - high-risk individual

KW - pancreatic ductal adenocarcinoma

KW - reporting template

KW - screening

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M3 - Article

C2 - 35856454

AN - SCOPUS:85142403061

SN - 0361-803X

VL - 219

SP - 903

EP - 914

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

IS - 6

ER -

Standardization of MRI Screening and Reporting in Individuals With Elevated Risk of Pancreatic Ductal Adenocarcinoma: Consensus Statement of the PRECEDE Consortium

Abstract

Keywords

ASJC Scopus subject areas

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