@article{2295db1cac2b4117ac9c974930f38cb3,
title = "Standard operating procedures for biospecimen collection, processing, and storage: From the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer",
abstract = "High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.",
keywords = "biorepository, biospecimens, pancreas, standard operating procedures",
author = "Fisher, {William E.} and Zobeida Cruz-Monserrate and McElhany, {Amy L.} and Lesinski, {Gregory B.} and Hart, {Phil A.} and Ria Ghosh and {Van Buren}, George and Fishman, {Douglas S.} and Rinaudo, {Jo Ann S.} and Jose Serrano and Sudhir Srivastava and Thomas MacE and Mark Topazian and Ziding Feng and Dhiraj Yadav and Pandol, {Stephen J.} and Hughes, {Steven J.} and Liu, {Robert Y.} and Emily Lu and Robert Orr and Whitcomb, {David C.} and Abouhamze, {Amer S.} and Hanno Steen and Sellers, {Zachary M.} and Troendle, {David M.} and Aliye Uc and Lowe, {Mark E.} and Conwell, {Darwin L.}",
note = "Funding Information: Research reported in this publication was supported by the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases under award numbers U01DK108326 (Baylor College of Medicine), U01DK108327 (Ohio State University), U01DK108328 (University of Texas MD Anderson Cancer Center), U01DK108288 (Mayo Clinic), U01DK108306 (University of Pittsburgh), U01DK108314 (Cedars-Sinai Medical Center), U01DK108320 (University Of Florida), U01DK108323 (Indiana University), U01DK108300 (Stanford University), and U01 DK108334 (University of Iowa). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding Information: W ell-annotated and characterized human biospecimens are needed to identify potentially diagnostic, prognostic, and predictive biomarkers.1 Through the acquisition of a cohort of well-characterized patients and associated biospecimens (blood, urine, saliva, stool, pancreatic and duodenal juice, stools, and when feasible pancreatic tissue), the proposed clinical research network will provide the resources and collaborative opportunities necessary for achieving many of the research objectives identified by the Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC). The CPDPC is supported by the National Cancer Institute (NCI) and the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) as a unique multidisciplinary model to study chronic pancreatitis, diabetes, and pancreatic cancer in both children and adults. Differences in Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2018",
month = nov,
day = "1",
doi = "10.1097/MPA.0000000000001171",
language = "English (US)",
volume = "47",
pages = "1213--1221",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "10",
}