Abstract
The chapter on stability and toxicity of contrast agents gives an update of thermodynamic and kinetic constants for new metal ion-ligand complexes that are explored as a potential MRI contrast agents. It also provides a brief overview of the computer programs used for the calculation of the equilibrium constants (protonation and stability constants). Next, the chapter talks about stability of metal-ligand complexes, including complexes of open chain ligands, complexes of tripodal and 6-amino-6-methylperhydro-1,4-diazepine tetraacetic acid (AAZTA) ligands, and complexes of macrocyclic ligands. It also includes ternary complexes formed between the Ln(L) complexes and various bio-ligands, Mn 2+-based contrast agents. Then, it explains formation kinetics and dissociation of M(L) complexes such as DOTA complexes and DOTA-tetraamides complexes. Finally, the chapter discusses biodistribution and in vivo toxicity of Gd3+-based MRI contrast agents.
Original language | English (US) |
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Title of host publication | The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging |
Subtitle of host publication | Second Edition |
Publisher | John Wiley and Sons |
Pages | 157-208 |
Number of pages | 52 |
ISBN (Print) | 9781119991762 |
DOIs | |
State | Published - Feb 18 2013 |
Keywords
- Equilibrium constants
- Gadolinium (3+)
- Kinetic inertness
- MRI contrast agents
- Metal-ligand complexes
- Thermodynamic stability
- in vivo toxicity
ASJC Scopus subject areas
- General Chemistry