Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Justin A. Bishop, James J. Sciubba, William H. Westra

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The most common malignancy to involve the oral cavity and oropharynx is squamous cell carcinoma (SCC). Because these oral cancers share an origin from the squamous epithelium, the pathology of oral SCC might be expected to be uniform and its diagnosis repetitive. In reality, the morphologic diversity in SCC, along with the propensity for reactive processes of the oral cavity to mimic SCC histologically, renders its diagnosis one of the more challenging in surgical pathology. This article discusses variants of oral and oropharyngeal SCC and highlights those features that help distinguish human papillomavirus-related from human papillomavirus-unrelated SCC.

Original languageEnglish (US)
Pages (from-to)1127-1151
Number of pages25
JournalSurgical Pathology Clinics
Issue number4
StatePublished - Dec 1 2011


  • Basaloid squamous cell carcinoma
  • Head and neck squamous cell carcinoma
  • Human papillomavirus
  • Necrotizing sialometaplasia
  • Papillary squamous cell carcinoma
  • Pseudoepitheliomatous hyperplasia
  • Spindle cell type: sarcomatoid carcinoma
  • Verrucous carcinoma

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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