Spontaneous neurotransmission: An independent pathway for neuronal signaling?

Ege T. Kavalali, ChiHye Chung, Mikhail Khvotchev, Jeremy Leitz, Elena Nosyreva, Jesica Raingo, Denise M O Ramirez

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Recent findings suggest that spontaneous neurotransmission is a bona fide pathway for interneuronal signaling that operates independent of evoked transmission via distinct presynaptic as well as postsynaptic substrates. This article will examine the role of spontaneous release events in neuronal signaling by focusing on aspects that distinguish this process from evoked neurotransmission, and evaluate the mechanisms that may underlie this segregation.

Original languageEnglish (US)
Pages (from-to)45-53
Number of pages9
Issue number1
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Physiology


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