Splenic phagocytic function in children with sickle cell anemia receiving long-term hypertransfusion therapy

George R. Buchanan, Virgil McKie, Elizabeth A. Jackson, Debra A. Vedro, Susan Hamner, Christine A. Holtkamp

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


To determine the effects of blood transfusions on splenic function in older patients with sickle cell anemia, we investigated splenic function in 12 patients who had had cerebrovascular accidents and who were being treated at two collaborating centers using different transfusion protocols. Splenic function was assessed by radionuclide scan and pocked erythrocyte count. Patients were 6 to 18 years of age and had been recelving transfusions for 7 months to 10 years (median 4.2 years). Of the 12 children, five had normal or increased splenic size and function (normal scan and normal or minimally elevated pocked erythrocyte count). All were recelving intensive transfusion therapy, with the aim of maintaining the hemoglobin S level at less than 20%. The other seven patients had abnormal splenic function (absent radionuclide uptake and elevated pocked erythrocyte count); each was receiving less intensive transfusion therapy, with the pretransfusion hemoglobin S level usually at 30% to 40%. No patient developed bacterial septicemia while receiving hypertransfusion therapy. We conclude that splenic function during a long-term transfusion program is variable, depending in part on the "intensity" of transfusion therapy. Apparent splenic involution and fibrosis may be a reversible event in some patients.

Original languageEnglish (US)
Pages (from-to)568-572
Number of pages5
JournalThe Journal of pediatrics
Issue number4
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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