Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation

M. B. Ooi; Z. Li; R. K. Robison; D. Wang; A. G. Anderson; N. R. Zwart; A. Bakhru; S. Nagaraj; T. Mathews; S. Hey; J. J. Koonen; I. E. Dimitrov; H. T. Friel; Q. Lu; M. Obara; I. Saha; H. Wang; Y. Wang; Y. Zhao; M. Temkit; H. H. Hu; T. L. Chenevert; O. Togao; J. A. Tkach; U. D. Nagaraj; M. C. Pinho; R. K. Gupta; J. E. Small; M. M. Kunst; J. P. Karis; J. B. Andre; J. H. Miller; N. K. Pinter; J. G. Pipe

doi:10.3174/ajnr.A6409

Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation

M. B. Ooi, Z. Li, R. K. Robison, D. Wang, A. G. Anderson, N. R. Zwart, A. Bakhru, S. Nagaraj, T. Mathews, S. Hey, J. J. Koonen, I. E. Dimitrov, H. T. Friel, Q. Lu, M. Obara, I. Saha, H. Wang, Y. Wang, Y. Zhao, M. TemkitH. H. Hu, T. L. Chenevert, O. Togao, J. A. Tkach, U. D. Nagaraj, M. C. Pinho, R. K. Gupta, J. E. Small, M. M. Kunst, J. P. Karis, J. B. Andre, J. H. Miller, N. K. Pinter, J. G. Pipe

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and purpose: Spiral MR imaging has several advantages compared with Cartesian MR imaging that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral with standard-of-care Cartesian postcontrast structural brain MR imaging on the basis of relative performance in 10 metrics of image quality, artifact prevalence, and diagnostic benefit. Materials and methods: Seven clinical sites acquired 88 total subjects. For each subject, sites acquired 2 postcontrast MR imaging scans: a spiral 2D T1 spin-echo, and 1 of 4 routine Cartesian 2D T1 spin-echo/TSE scans (fully sampled spin-echo at 3T, 1.5T, partial Fourier, TSE). The spiral acquisition matched the Cartesian scan for scan time, geometry, and contrast. Nine neuroradiologists independently reviewed each subject, with the matching pair of spiral and Cartesian scans compared side-by-side, and scored on 10 image-quality metrics (5-point Likert scale) focused on intracranial assessment. The Wilcoxon signed rank test evaluated relative performance of spiral versus Cartesian, while the Kruskal-Wallis test assessed interprotocol differences. Results: Spiral was superior to Cartesian in 7 of 10 metrics (flow artifact mitigation, SNR, GM/WM contrast, image sharpness, lesion conspicuity, preference for diagnosing abnormal enhancement, and overall intracranial image quality), comparable in 1 of 10 metrics (motion artifacts), and inferior in 2 of 10 metrics (susceptibility artifacts, overall extracranial image quality) related to magnetic susceptibility (P < .05). Interprotocol comparison confirmed relatively higher SNR and GM/WM contrast for partial Fourier and TSE protocol groups, respectively (P < .05). Conclusions: Spiral 2D T1 spin-echo for routine structural brain MR imaging is feasible in the clinic with conventional scanners and was preferred by neuroradiologists for overall postcontrast intracranial evaluation.

Original language	English (US)
Pages (from-to)	238-245
Number of pages	8
Journal	American Journal of Neuroradiology
Volume	41
Issue number	2
DOIs	https://doi.org/10.3174/ajnr.A6409
State	Published - Feb 1 2020

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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Ooi, M. B., Li, Z., Robison, R. K., Wang, D., Anderson, A. G., Zwart, N. R., Bakhru, A., Nagaraj, S., Mathews, T., Hey, S., Koonen, J. J., Dimitrov, I. E., Friel, H. T., Lu, Q., Obara, M., Saha, I., Wang, H., Wang, Y., Zhao, Y., ... Pipe, J. G. (2020). Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation. American Journal of Neuroradiology, 41(2), 238-245. https://doi.org/10.3174/ajnr.A6409

Ooi, MB, Li, Z, Robison, RK, Wang, D, Anderson, AG, Zwart, NR, Bakhru, A, Nagaraj, S, Mathews, T, Hey, S, Koonen, JJ, Dimitrov, IE, Friel, HT, Lu, Q, Obara, M, Saha, I, Wang, H, Wang, Y, Zhao, Y, Temkit, M, Hu, HH, Chenevert, TL, Togao, O, Tkach, JA, Nagaraj, UD, Pinho, MC, Gupta, RK, Small, JE, Kunst, MM, Karis, JP, Andre, JB, Miller, JH, Pinter, NK & Pipe, JG 2020, 'Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation', American Journal of Neuroradiology, vol. 41, no. 2, pp. 238-245. https://doi.org/10.3174/ajnr.A6409

@article{172a93f8714a413c8fbf1501fe093e5f,

title = "Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation",

abstract = "Background and purpose: Spiral MR imaging has several advantages compared with Cartesian MR imaging that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral with standard-of-care Cartesian postcontrast structural brain MR imaging on the basis of relative performance in 10 metrics of image quality, artifact prevalence, and diagnostic benefit. Materials and methods: Seven clinical sites acquired 88 total subjects. For each subject, sites acquired 2 postcontrast MR imaging scans: a spiral 2D T1 spin-echo, and 1 of 4 routine Cartesian 2D T1 spin-echo/TSE scans (fully sampled spin-echo at 3T, 1.5T, partial Fourier, TSE). The spiral acquisition matched the Cartesian scan for scan time, geometry, and contrast. Nine neuroradiologists independently reviewed each subject, with the matching pair of spiral and Cartesian scans compared side-by-side, and scored on 10 image-quality metrics (5-point Likert scale) focused on intracranial assessment. The Wilcoxon signed rank test evaluated relative performance of spiral versus Cartesian, while the Kruskal-Wallis test assessed interprotocol differences. Results: Spiral was superior to Cartesian in 7 of 10 metrics (flow artifact mitigation, SNR, GM/WM contrast, image sharpness, lesion conspicuity, preference for diagnosing abnormal enhancement, and overall intracranial image quality), comparable in 1 of 10 metrics (motion artifacts), and inferior in 2 of 10 metrics (susceptibility artifacts, overall extracranial image quality) related to magnetic susceptibility (P < .05). Interprotocol comparison confirmed relatively higher SNR and GM/WM contrast for partial Fourier and TSE protocol groups, respectively (P < .05). Conclusions: Spiral 2D T1 spin-echo for routine structural brain MR imaging is feasible in the clinic with conventional scanners and was preferred by neuroradiologists for overall postcontrast intracranial evaluation.",

author = "Ooi, {M. B.} and Z. Li and Robison, {R. K.} and D. Wang and Anderson, {A. G.} and Zwart, {N. R.} and A. Bakhru and S. Nagaraj and T. Mathews and S. Hey and Koonen, {J. J.} and Dimitrov, {I. E.} and Friel, {H. T.} and Q. Lu and M. Obara and I. Saha and H. Wang and Y. Wang and Y. Zhao and M. Temkit and Hu, {H. H.} and Chenevert, {T. L.} and O. Togao and Tkach, {J. A.} and Nagaraj, {U. D.} and Pinho, {M. C.} and Gupta, {R. K.} and Small, {J. E.} and Kunst, {M. M.} and Karis, {J. P.} and Andre, {J. B.} and Miller, {J. H.} and Pinter, {N. K.} and Pipe, {J. G.}",

year = "2020",

month = feb,

day = "1",

doi = "10.3174/ajnr.A6409",

language = "English (US)",

volume = "41",

pages = "238--245",

journal = "American Journal of Neuroradiology",

issn = "0195-6108",

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number = "2",

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TY - JOUR

T1 - Spiral T1 spin-echo for routine postcontrast brain MRI exams

T2 - A multicenter multireader clinical evaluation

AU - Ooi, M. B.

AU - Li, Z.

AU - Robison, R. K.

AU - Wang, D.

AU - Anderson, A. G.

AU - Zwart, N. R.

AU - Bakhru, A.

AU - Nagaraj, S.

AU - Mathews, T.

AU - Hey, S.

AU - Koonen, J. J.

AU - Dimitrov, I. E.

AU - Friel, H. T.

AU - Lu, Q.

AU - Obara, M.

AU - Saha, I.

AU - Wang, H.

AU - Wang, Y.

AU - Zhao, Y.

AU - Temkit, M.

AU - Hu, H. H.

AU - Chenevert, T. L.

AU - Togao, O.

AU - Tkach, J. A.

AU - Nagaraj, U. D.

AU - Pinho, M. C.

AU - Gupta, R. K.

AU - Small, J. E.

AU - Kunst, M. M.

AU - Karis, J. P.

AU - Andre, J. B.

AU - Miller, J. H.

AU - Pinter, N. K.

AU - Pipe, J. G.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Background and purpose: Spiral MR imaging has several advantages compared with Cartesian MR imaging that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral with standard-of-care Cartesian postcontrast structural brain MR imaging on the basis of relative performance in 10 metrics of image quality, artifact prevalence, and diagnostic benefit. Materials and methods: Seven clinical sites acquired 88 total subjects. For each subject, sites acquired 2 postcontrast MR imaging scans: a spiral 2D T1 spin-echo, and 1 of 4 routine Cartesian 2D T1 spin-echo/TSE scans (fully sampled spin-echo at 3T, 1.5T, partial Fourier, TSE). The spiral acquisition matched the Cartesian scan for scan time, geometry, and contrast. Nine neuroradiologists independently reviewed each subject, with the matching pair of spiral and Cartesian scans compared side-by-side, and scored on 10 image-quality metrics (5-point Likert scale) focused on intracranial assessment. The Wilcoxon signed rank test evaluated relative performance of spiral versus Cartesian, while the Kruskal-Wallis test assessed interprotocol differences. Results: Spiral was superior to Cartesian in 7 of 10 metrics (flow artifact mitigation, SNR, GM/WM contrast, image sharpness, lesion conspicuity, preference for diagnosing abnormal enhancement, and overall intracranial image quality), comparable in 1 of 10 metrics (motion artifacts), and inferior in 2 of 10 metrics (susceptibility artifacts, overall extracranial image quality) related to magnetic susceptibility (P < .05). Interprotocol comparison confirmed relatively higher SNR and GM/WM contrast for partial Fourier and TSE protocol groups, respectively (P < .05). Conclusions: Spiral 2D T1 spin-echo for routine structural brain MR imaging is feasible in the clinic with conventional scanners and was preferred by neuroradiologists for overall postcontrast intracranial evaluation.

AB - Background and purpose: Spiral MR imaging has several advantages compared with Cartesian MR imaging that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral with standard-of-care Cartesian postcontrast structural brain MR imaging on the basis of relative performance in 10 metrics of image quality, artifact prevalence, and diagnostic benefit. Materials and methods: Seven clinical sites acquired 88 total subjects. For each subject, sites acquired 2 postcontrast MR imaging scans: a spiral 2D T1 spin-echo, and 1 of 4 routine Cartesian 2D T1 spin-echo/TSE scans (fully sampled spin-echo at 3T, 1.5T, partial Fourier, TSE). The spiral acquisition matched the Cartesian scan for scan time, geometry, and contrast. Nine neuroradiologists independently reviewed each subject, with the matching pair of spiral and Cartesian scans compared side-by-side, and scored on 10 image-quality metrics (5-point Likert scale) focused on intracranial assessment. The Wilcoxon signed rank test evaluated relative performance of spiral versus Cartesian, while the Kruskal-Wallis test assessed interprotocol differences. Results: Spiral was superior to Cartesian in 7 of 10 metrics (flow artifact mitigation, SNR, GM/WM contrast, image sharpness, lesion conspicuity, preference for diagnosing abnormal enhancement, and overall intracranial image quality), comparable in 1 of 10 metrics (motion artifacts), and inferior in 2 of 10 metrics (susceptibility artifacts, overall extracranial image quality) related to magnetic susceptibility (P < .05). Interprotocol comparison confirmed relatively higher SNR and GM/WM contrast for partial Fourier and TSE protocol groups, respectively (P < .05). Conclusions: Spiral 2D T1 spin-echo for routine structural brain MR imaging is feasible in the clinic with conventional scanners and was preferred by neuroradiologists for overall postcontrast intracranial evaluation.

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Spiral T1 spin-echo for routine postcontrast brain MRI exams: A multicenter multireader clinical evaluation

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