Spinal Cord Tolerance and Risk of Radiation Myelopathy

Majed Alghamdi; Shun Wong; Paul Medin; Lijun Ma; Beibei Zhang; Sten Myrehaug; Chia Lin Tseng; Hany Soliman; Arjun Sahgal

doi:10.1007/978-3-031-67878-3_36

Spinal Cord Tolerance and Risk of Radiation Myelopathy

Majed Alghamdi, Shun Wong, Paul Medin, Lijun Ma, Beibei Zhang, Sten Myrehaug, Chia Lin Tseng, Hany Soliman, Arjun Sahgal

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Radiation myelopathy (RM) is one of the most feared complications of radiation therapy. It is a diagnosis of exclusion based on both clinical and radiographic findings. Safe spinal cord dose limits have been derived from preclinical and limited human clinical dosimetric data. The doses to the spinal cord associated with a clinically acceptable risk of RM (=5%) vary depending on dose per fraction, technique, previous radiation treatment, and time interval between radiation courses. When appropriate spinal cord dose limits are applied, RM is considered rare event. This chapter will summarize the data, specific to both conventionally fractionated radiation (1.8-2.0 Gy/fraction) and high-dose stereotactic body radiotherapy (>5 Gy/fraction), as to spinal cord tolerance and recommendations for safe practice.

Original language	English (US)
Title of host publication	Adult CNS Radiation Oncology
Subtitle of host publication	Principles and Practice: Second Edition
Publisher	Springer Nature
Pages	581-597
Number of pages	17
ISBN (Electronic)	9783031678783
ISBN (Print)	9783031678776
DOIs	https://doi.org/10.1007/978-3-031-67878-3_36
State	Published - Jan 1 2024
Externally published	Yes

Keywords

Late effects
Radiation myelopathy
Spinal cord
Spinal cord tolerance
Stereotactic body radiotherapy

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1007/978-3-031-67878-3_36

Cite this

@inbook{22ccb92d63054099a1b7d98dee253eac,

title = "Spinal Cord Tolerance and Risk of Radiation Myelopathy",

abstract = "Radiation myelopathy (RM) is one of the most feared complications of radiation therapy. It is a diagnosis of exclusion based on both clinical and radiographic findings. Safe spinal cord dose limits have been derived from preclinical and limited human clinical dosimetric data. The doses to the spinal cord associated with a clinically acceptable risk of RM (=5%) vary depending on dose per fraction, technique, previous radiation treatment, and time interval between radiation courses. When appropriate spinal cord dose limits are applied, RM is considered rare event. This chapter will summarize the data, specific to both conventionally fractionated radiation (1.8-2.0 Gy/fraction) and high-dose stereotactic body radiotherapy (>5 Gy/fraction), as to spinal cord tolerance and recommendations for safe practice.",

keywords = "Late effects, Radiation myelopathy, Spinal cord, Spinal cord tolerance, Stereotactic body radiotherapy",

author = "Majed Alghamdi and Shun Wong and Paul Medin and Lijun Ma and Beibei Zhang and Sten Myrehaug and Tseng, {Chia Lin} and Hany Soliman and Arjun Sahgal",

note = "Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2018, 2024.",

year = "2024",

month = jan,

day = "1",

doi = "10.1007/978-3-031-67878-3_36",

language = "English (US)",

isbn = "9783031678776",

pages = "581--597",

booktitle = "Adult CNS Radiation Oncology",

publisher = "Springer Nature",

address = "United States",

}

TY - CHAP

T1 - Spinal Cord Tolerance and Risk of Radiation Myelopathy

AU - Alghamdi, Majed

AU - Wong, Shun

AU - Medin, Paul

AU - Ma, Lijun

AU - Zhang, Beibei

AU - Myrehaug, Sten

AU - Tseng, Chia Lin

AU - Soliman, Hany

AU - Sahgal, Arjun

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2018, 2024.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Radiation myelopathy (RM) is one of the most feared complications of radiation therapy. It is a diagnosis of exclusion based on both clinical and radiographic findings. Safe spinal cord dose limits have been derived from preclinical and limited human clinical dosimetric data. The doses to the spinal cord associated with a clinically acceptable risk of RM (=5%) vary depending on dose per fraction, technique, previous radiation treatment, and time interval between radiation courses. When appropriate spinal cord dose limits are applied, RM is considered rare event. This chapter will summarize the data, specific to both conventionally fractionated radiation (1.8-2.0 Gy/fraction) and high-dose stereotactic body radiotherapy (>5 Gy/fraction), as to spinal cord tolerance and recommendations for safe practice.

AB - Radiation myelopathy (RM) is one of the most feared complications of radiation therapy. It is a diagnosis of exclusion based on both clinical and radiographic findings. Safe spinal cord dose limits have been derived from preclinical and limited human clinical dosimetric data. The doses to the spinal cord associated with a clinically acceptable risk of RM (=5%) vary depending on dose per fraction, technique, previous radiation treatment, and time interval between radiation courses. When appropriate spinal cord dose limits are applied, RM is considered rare event. This chapter will summarize the data, specific to both conventionally fractionated radiation (1.8-2.0 Gy/fraction) and high-dose stereotactic body radiotherapy (>5 Gy/fraction), as to spinal cord tolerance and recommendations for safe practice.

KW - Late effects

KW - Radiation myelopathy

KW - Spinal cord

KW - Spinal cord tolerance

KW - Stereotactic body radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=105001897892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=105001897892&partnerID=8YFLogxK

U2 - 10.1007/978-3-031-67878-3_36

DO - 10.1007/978-3-031-67878-3_36

M3 - Chapter

AN - SCOPUS:105001897892

SN - 9783031678776

SP - 581

EP - 597

BT - Adult CNS Radiation Oncology

PB - Springer Nature

ER -

Spinal Cord Tolerance and Risk of Radiation Myelopathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this