Spermidine Promotes Cardioprotective Autophagy

Dan Tong; Joseph A Hill

doi:10.1161/CIRCRESAHA.117.310603

Spermidine Promotes Cardioprotective Autophagy

Dan Tong, Joseph A Hill

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses agingassociated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.

Original language	English (US)
Pages (from-to)	1229-1231
Number of pages	3
Journal	Circulation research
Volume	120
Issue number	8
DOIs	https://doi.org/10.1161/CIRCRESAHA.117.310603
State	Published - Apr 14 2017

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/CIRCRESAHA.117.310603

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title = "Spermidine Promotes Cardioprotective Autophagy",

abstract = "A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses agingassociated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.",

author = "Dan Tong and Hill, {Joseph A}",

note = "Funding Information: This study was supported by grants from the National Institutes of Health (HL-120732 and HL-100401 to Dr Hill), American Heart Association (14SFRN20740000 to Dr Hill), CPRIT (Cancer Prevention and Research Institute of Texas; RP110486P3 to Dr Hill), and the Leducq Foundation (11CVD04 to Dr Hill).",

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doi = "10.1161/CIRCRESAHA.117.310603",

language = "English (US)",

volume = "120",

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AU - Tong, Dan

AU - Hill, Joseph A

N1 - Funding Information: This study was supported by grants from the National Institutes of Health (HL-120732 and HL-100401 to Dr Hill), American Heart Association (14SFRN20740000 to Dr Hill), CPRIT (Cancer Prevention and Research Institute of Texas; RP110486P3 to Dr Hill), and the Leducq Foundation (11CVD04 to Dr Hill).

PY - 2017/4/14

Y1 - 2017/4/14

N2 - A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses agingassociated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.

AB - A recent study published in Nature Medicine reports that dietary supplementation with spermidine, a natural polyamine, extends life span and reverses agingassociated cardiac dysfunction in mice through induction of autophagy. Similar protective effects of spermidine on human cardiovascular health were also suggested by epidemiological studies.

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DO - 10.1161/CIRCRESAHA.117.310603

M3 - Review article

C2 - 28408448

AN - SCOPUS:85017420344

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Spermidine Promotes Cardioprotective Autophagy

Abstract

ASJC Scopus subject areas

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