@article{6d3638df7f964a6e919d9994467ae49a,
title = "Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients",
abstract = "Hypertension (HT) is a systemic disorder that results in the decline of quality of life and death. While patients with periodontitis are at a high risk of HT, little causal information has been provided to date. To clarify the relationship, periodontopathic bacterial infection in cardiovascular patients with or without HT was evaluated. The subjects were patients with (n = 412) or without (n = 199) HT who attended Tokyo Medical and Dental University hospital. Blood examinations and periodontal measurements were performed. Three periodontopathic bacteria existence and antibody titers were evaluated. We found that specific periodontopathic bacteria, Aggregatibacter actinomycetemcomitans and Prevotella intermedia, were highly detected in male subjects with HT compared to non-HT subjects, while they were comparable in the female patients. Mean probing pocket depth of elderly male patients with HT was higher compared to non-HT patients. The rates of obesity, dyslipidemia, and diabetes showed partial statistical difference between the two groups. Specific periodontopathic bacterial infection may affect HT in male cardiovascular patients.",
keywords = "Bacteria, Cardiovascular disease, Hypertension, Periodontal disease",
author = "Norio Aoyama and Suzuki, {Jun ichi} and Hidetoshi Kumagai and Yuichi Ikeda and Hiroshi Akazawa and Issei Komuro and Masato Minabe and Yuichi Izumi and Mitsuaki Isobe",
note = "Funding Information: The authors wish to thank Dr. Naho Kobayashi, Dr. Tomoya Hanatani, Dr. Norihiko Ashigaki, Dr. Yuka Shiheido, Dr. Makoto Kaneko, Dr. Hiroki Sato, Dr. Katsuhiko Matsuo, and Dr. Chisato Takamura for excellent assistance. This work was supported by JSPS KAKENHI Grant Numbers (JP25870198 and JP16H05824), Ministry of Education, Culture, Sports, Science and Technology of Japan, Mitsui Life Insurance Research Foundation, Mitsui Sumitomo Marine Welfare Research Foundation, Geriatric Dental Research Foundation, Human Health Future Research Foundation, St. Luke?s Hospital Research Foundation, Health Management Foundation, Taiyo Life Insurance Research Foundation, The 8020 Promotion Foundation, Terumo Science Foundation, Pfizer Health Research Foundation, General Health Promotion Foundation, Suzuken Memorial Foundation, Health Science Center Foundation, Kobayashi International Scholarship Foundation, and Hakujikai Institute of Gerontology Foundation. All authors declared that they have no potential conflict of interest. Funding Information: Acknowledgements The authors wish to thank Dr. Naho Kobayashi, Dr. Tomoya Hanatani, Dr. Norihiko Ashigaki, Dr. Yuka Shiheido, Dr. Makoto Kaneko, Dr. Hiroki Sato, Dr. Katsuhiko Matsuo, and Dr. Chisato Takamura for excellent assistance. This work was supported by JSPS KAKENHI Grant Numbers (JP25870198 and JP16H05824), Ministry of Education, Culture, Sports, Science and Technology of Japan, Mitsui Life Insurance Research Foundation, Mitsui Sumitomo Marine Welfare Research Foundation, Geriatric Dental Research Foundation, Human Health Future Research Foundation, St. Luke{\textquoteright}s Hospital Research Foundation, Health Management Foundation, Taiyo Life Insurance Research Foundation, The 8020 Promotion Foundation, Terumo Science Foundation, Pfizer Health Research Foundation, General Health Promotion Foundation, Suzuken Memorial Foundation, Health Science Center Foundation, Kobayashi International Scholarship Foundation, and Hakujikai Institute of Gerontology Foundation. Publisher Copyright: {\textcopyright} 2017, Springer Japan KK.",
year = "2018",
month = feb,
day = "1",
doi = "10.1007/s00380-017-1042-z",
language = "English (US)",
volume = "33",
pages = "198--204",
journal = "Heart and Vessels",
issn = "0910-8327",
publisher = "Springer Japan",
number = "2",
}