Abstract
The effect of anti-Ia alloantiserum on the capacity of selected peritoneal exudate lymphocytes (selected PEL) to bind to antigen-pulsed F1 (responder x nonresponder) macrophages was investigated. With the use of selected PEL for antigens under Ir gene control, it was shown that anti-Ia serum to the responder haplotype blocked adherence of selected PEL to antigen-pulsed macrophages whereas anti-Ia serum to the nonresponder haplotype did not. The target cell of the anti-Ia alloantiserum appeared to be the macrophage because anti-13 Ia in contrast to anti-2 Ia did not inhibit binding of F1 (2 x 13) DNP-GL (GL = copolymer of L-glutamic acid and L-tyrosine) selected PEL to DNP-GL pulsed strain-2 Mφ (responder strain). Taken together with previous experiments that indicate that an antibody to the native protein antigen employed is unable to block specific binding, the present results suggest that T cells may recognize fragments of exogenous antigen in association with Ia molecules.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1598-1600 |
| Number of pages | 3 |
| Journal | Journal of Immunology |
| Volume | 122 |
| Issue number | 4 |
| State | Published - Dec 1 1979 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology