Special Considerations in the Care of Women With Advanced Heart Failure

Imo A. Ebong, Ersilia M. DeFilippis, Eman A. Hamad, Eileen M. Hsich, Varinder K. Randhawa, Filio Billia, Mahwash Kassi, Anju Bhardwaj, Mirnela Byku, Mrudala R. Munagala, Roopa A. Rao, Amy E. Hackmann, Claudia G. Gidea, Teresa DeMarco, Shelley A. Hall

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Advanced heart failure (AHF) is associated with increased morbidity and mortality, and greater healthcare utilization. Recognition requires a thorough clinical assessment and appropriate risk stratification. There are persisting inequities in the allocation of AHF therapies. Women are less likely to be referred for evaluation of candidacy for heart transplantation or left ventricular assist device despite facing a higher risk of AHF-related mortality. Sex-specific risk factors influence progression to advanced disease and should be considered when evaluating women for advanced therapies. The purpose of this review is to discuss the role of sex hormones on the pathophysiology of AHF, describe the clinical presentation, diagnostic evaluation and definitive therapies of AHF in women with special attention to pregnancy, lactation, contraception and menopause. Future studies are needed to address areas of equipoise in the care of women with AHF.

Original languageEnglish (US)
Article number890108
JournalFrontiers in Cardiovascular Medicine
StatePublished - Jul 11 2022


  • advanced heart failure
  • advanced therapies (ATs)
  • heart transplant
  • ventricular assist device
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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