@article{b200973a79cc49afbb415458f7ae75a0,
title = "Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation",
abstract = "The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the unique characteristic of exhibiting neurogenesis persisting into adulthood. Despite their small numbers and sparse activity, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory function during sleep is unknown. Here, we investigate whether young ABN activity contributes to memory consolidation during sleep using Ca2+ imaging in freely moving mice. We found that contextual fear learning recruits a population of young ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity. Optogenetic silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on ABN dendrites and impairs memory consolidation. These findings provide a causal link between ABN activity during REM sleep and memory consolidation.",
keywords = "REM sleep, adult neurogenesis, calcium imaging, memory consolidation, miniaturized microscope, optogenetics",
author = "Deependra Kumar and Iyo Koyanagi and Alvaro Carrier-Ruiz and Pablo Vergara and Sakthivel Srinivasan and Yuki Sugaya and Masatoshi Kasuya and Yu, {Tzong Shiue} and Vogt, {Kaspar E.} and Masafumi Muratani and Takaaki Ohnishi and Sima Singh and Teixeira, {Catia M.} and Yoan Ch{\'e}rasse and Toshie Naoi and Wang, {Szu Han} and Pimpimon Nondhalee and Osman, {Boran A.H.} and Naoko Kaneko and Kazunobu Sawamoto and Kernie, {Steven G.} and Takeshi Sakurai and McHugh, {Thomas J.} and Masanobu Kano and Masashi Yanagisawa and Masanori Sakaguchi",
note = "Funding Information: We thank G. Kempermann and K.G. Akers for comments on the manuscript. We thank all WPI-IIIS members; T. Tezuka, S. Yaghisita, K. Kobayakawa, R. Kobayakawa, K. Shikama, S. Sugimori, N. Hasegawa, T. Hosokawa, A. Oba, and Y. Mimura for technical assistance; and J. Naughton (GT3 Core Facility of the Salk Institute) for retroviral preparation. This work was partially supported by grants from the World Premier International Research Center Initiative from MEXT , JST CREST (grant JPMJCR1655 ), JSPS KAKENHI (grants 16K18359 , 15F15408 , 26115502 , 25116530 , JP16H06280 , 19F19310 , and 20H03552 ), Takeda Science Foundation , Shimadzu Science Foundation , Kanae Foundation , Research Foundation for Opto-Science and Technology , Ichiro Kanehara Foundation , Kato Memorial Bioscience Foundation , Japan Foundation for Applied Enzymology , SENSHIN Medical Research Foundation , Life Science Foundation of Japan , Uehara Memorial Foundation , Brain Science Foundation , Kowa Life Science Foundation , Inamori Research Grants Program , and GSK Japan (to M.S.); JSPS KAKENHI (grants 25000015 and 18H04012 to M. Kano); Tokyo Biochemical Research Foundation and JSPS FPD (to S. Srinivasan); and JSPS FPD (to D.K.). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = aug,
day = "5",
doi = "10.1016/j.neuron.2020.05.008",
language = "English (US)",
volume = "107",
pages = "552--565.e10",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",
}