Sorting out signals in fly endosomes

Helmut Krämer

doi:10.1034/j.1600-0854.2002.030201.x

Sorting out signals in fly endosomes

Helmut Krämer

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Ligands and receptors that mediate cell-cell interactions during development are removed from the cell surface by endocytosis. Subsequently, many of these internalized proteins are detected in multivesicular bodies (MVBs). Recent work in different organisms has elucidated some aspects of MVB biogenesis and trafficking. This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila.

Original language	English (US)
Pages (from-to)	87-91
Number of pages	5
Journal	Traffic
Volume	3
Issue number	2
DOIs	https://doi.org/10.1034/j.1600-0854.2002.030201.x
State	Published - 2002

Keywords

Delivery
EGF receptor
Exosomes
Lysosomal MVBs
Mono-ubiquitination
Notch
Wingless

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1034/j.1600-0854.2002.030201.x

Cite this

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title = "Sorting out signals in fly endosomes",

abstract = "Ligands and receptors that mediate cell-cell interactions during development are removed from the cell surface by endocytosis. Subsequently, many of these internalized proteins are detected in multivesicular bodies (MVBs). Recent work in different organisms has elucidated some aspects of MVB biogenesis and trafficking. This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila.",

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PY - 2002

Y1 - 2002

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AB - Ligands and receptors that mediate cell-cell interactions during development are removed from the cell surface by endocytosis. Subsequently, many of these internalized proteins are detected in multivesicular bodies (MVBs). Recent work in different organisms has elucidated some aspects of MVB biogenesis and trafficking. This review discusses some intriguing links between these findings, the sorting of proteins in endocytic trafficking, and the regulation of signaling pathways in Drosophila.

KW - Delivery

KW - EGF receptor

KW - Exosomes

KW - Lysosomal MVBs

KW - Mono-ubiquitination

KW - Notch

KW - Wingless

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DO - 10.1034/j.1600-0854.2002.030201.x

M3 - Review article

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AN - SCOPUS:0036104999

SN - 1398-9219

VL - 3

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EP - 91

JO - Traffic

JF - Traffic

IS - 2

ER -

Sorting out signals in fly endosomes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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