Soluble αklotho as a candidate for the biomarker of aging

Daisuke Koyama, Yu Sato, Masato Aizawa, Takumi Maki, Masaki Kurosawa, Makoto Kuro-O, Yusuke Furukawa

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Although the Klotho gene has been recognized as an aging-suppressor gene, the significance of its soluble product, soluble αKlotho (sKlotho), in aging remains to be elucidated. To address this issue, we conducted a single-centered cross-sectional study in a region with a high prevalence of aging. We compared sKlotho levels with the patient characteristics from medical records and laboratory measurements, including fibroblast growth factor 23 (FGF23), intact parathyroid hormone, activated Vitamin D3 and factors associated with mineral bone metabolism, in 52 outpatients with a mean age of 78.2 years. Serum sKlotho levels significantly decreased with age, but were not associated with the stage of chronic kidney disease (CKD). Serum FGF23 levels increased as CKD stages advanced, but were not associated with aging. Univariate analyses revealed that sKlotho levels positively correlated with glomerular filtration rate, and negatively with age and serum levels of FGF23 and phosphorus. In a multivariable linear regression analysis, sKlotho significantly correlated with aging and lower FGF23 levels. Only osteoporosis affected sKlotho and FGF23 levels among the various complications and patient status including medication. In summary, serum sKlotho levels inversely correlated with age and FGF23, and were significantly reduced in patients with osteoporosis. sKlotho may serve as a biomarker of aging independent of renal function.

Original languageEnglish (US)
Pages (from-to)1019-1025
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number4
StatePublished - Nov 27 2015


  • Aging
  • Chronic kidney disease
  • FGF23
  • Klotho
  • Osteoporosis
  • Soluble αKlotho

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Soluble αklotho as a candidate for the biomarker of aging'. Together they form a unique fingerprint.

Cite this