Soluble adenylyl cyclase: Potential role in mineral metabolism

Weidong Geng, Orson W. Moe

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The conversion of a signal of inorganic ion concentration to a second messenger is of fundamental biologic significance. The soluble adenylyl cyclase (sAC) serves such a purpose by transducing divalent cation concentrations and bicarbonate concentrations into intracellular cyclic AMP levels. sAC is widely expressed and may represent a generic bicarbonate sensor providing the afferent pathway to bicarbonate-regulated biologic processes. The best described action of sAC to date is in the mediation of bicarbonate-induced changes in sperm motility. Since a number of processes in mineral metabolism - such as bone formation, bone resorption, intestinal calcium absorption, and renal calcium transport in the distal convoluted tubule - are regulated by bicarbonate, sAC may play a role at multiple levels in mineral metabolism.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
Number of pages8
StatePublished - May 11 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Other1st Annual International Urolithiasis Research Symposium
Country/TerritoryUnited States
CityIndianapolis, IN


  • Calcium
  • Second messengers

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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