TY - JOUR
T1 - Soluble αklotho as a candidate for the biomarker of aging
AU - Koyama, Daisuke
AU - Sato, Yu
AU - Aizawa, Masato
AU - Maki, Takumi
AU - Kurosawa, Masaki
AU - Kuro-O, Makoto
AU - Furukawa, Yusuke
N1 - Funding Information:
This work was supported by a research grant from the Fukushima Prefectural Hospitals Bureau . We would like to thank Sachiko Kimura, Toyoko Kanke, Miyuki Ichijo, Saori Saito, Shouko Furukawa and Eiji Togawa for collecting the patient samples.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/11/27
Y1 - 2015/11/27
N2 - Although the Klotho gene has been recognized as an aging-suppressor gene, the significance of its soluble product, soluble αKlotho (sKlotho), in aging remains to be elucidated. To address this issue, we conducted a single-centered cross-sectional study in a region with a high prevalence of aging. We compared sKlotho levels with the patient characteristics from medical records and laboratory measurements, including fibroblast growth factor 23 (FGF23), intact parathyroid hormone, activated Vitamin D3 and factors associated with mineral bone metabolism, in 52 outpatients with a mean age of 78.2 years. Serum sKlotho levels significantly decreased with age, but were not associated with the stage of chronic kidney disease (CKD). Serum FGF23 levels increased as CKD stages advanced, but were not associated with aging. Univariate analyses revealed that sKlotho levels positively correlated with glomerular filtration rate, and negatively with age and serum levels of FGF23 and phosphorus. In a multivariable linear regression analysis, sKlotho significantly correlated with aging and lower FGF23 levels. Only osteoporosis affected sKlotho and FGF23 levels among the various complications and patient status including medication. In summary, serum sKlotho levels inversely correlated with age and FGF23, and were significantly reduced in patients with osteoporosis. sKlotho may serve as a biomarker of aging independent of renal function.
AB - Although the Klotho gene has been recognized as an aging-suppressor gene, the significance of its soluble product, soluble αKlotho (sKlotho), in aging remains to be elucidated. To address this issue, we conducted a single-centered cross-sectional study in a region with a high prevalence of aging. We compared sKlotho levels with the patient characteristics from medical records and laboratory measurements, including fibroblast growth factor 23 (FGF23), intact parathyroid hormone, activated Vitamin D3 and factors associated with mineral bone metabolism, in 52 outpatients with a mean age of 78.2 years. Serum sKlotho levels significantly decreased with age, but were not associated with the stage of chronic kidney disease (CKD). Serum FGF23 levels increased as CKD stages advanced, but were not associated with aging. Univariate analyses revealed that sKlotho levels positively correlated with glomerular filtration rate, and negatively with age and serum levels of FGF23 and phosphorus. In a multivariable linear regression analysis, sKlotho significantly correlated with aging and lower FGF23 levels. Only osteoporosis affected sKlotho and FGF23 levels among the various complications and patient status including medication. In summary, serum sKlotho levels inversely correlated with age and FGF23, and were significantly reduced in patients with osteoporosis. sKlotho may serve as a biomarker of aging independent of renal function.
KW - Aging
KW - Chronic kidney disease
KW - FGF23
KW - Klotho
KW - Osteoporosis
KW - Soluble αKlotho
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U2 - 10.1016/j.bbrc.2015.10.018
DO - 10.1016/j.bbrc.2015.10.018
M3 - Article
C2 - 26462468
AN - SCOPUS:84946542262
SN - 0006-291X
VL - 467
SP - 1019
EP - 1025
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -