In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Mar 4 2011|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology