Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation

Bryan A. Gibson; W. Lee Kraus

doi:10.1016/j.molcel.2011.02.019

Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation

Bryan A. Gibson, W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.

Original language	English (US)
Pages (from-to)	497-499
Number of pages	3
Journal	Molecular cell
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2011.02.019
State	Published - Mar 4 2011

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2011.02.019

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title = "Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation",

abstract = "In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.",

author = "Gibson, {Bryan A.} and Kraus, {W. Lee}",

year = "2011",

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AU - Gibson, Bryan A.

AU - Kraus, W. Lee

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Y1 - 2011/3/4

N2 - In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.

AB - In this issue of Molecular Cell, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the HO-1 locus in mammalian cells and exhibits transcriptional corepressor activity through local production of S-adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.

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DO - 10.1016/j.molcel.2011.02.019

M3 - Short survey

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JO - Molecular cell

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IS - 5

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Small Molecules, Big Effects: A Role for Chromatin-Localized Metabolite Biosynthesis in Gene Regulation

Abstract

ASJC Scopus subject areas

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