Small molecule modifiers of circadian clocks

Zheng Chen, Seung Hee Yoo, Joseph S. Takahashi

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Circadian clocks orchestrate 24-h oscillations of essential physiological and behavioral processes in response to daily environmental changes. These clocks are remarkably precise under constant conditions yet highly responsive to resetting signals. With the molecular composition of the core oscillator largely established, recent research has increasingly focused on clock-modifying mechanisms/molecules. In particular, small molecule modifiers, intrinsic or extrinsic, are emerging as powerful tools for understanding basic clock biology as well as developing putative therapeutic agents for clock-associated diseases. In this review, we will focus on synthetic compounds capable of modifying the period, phase, or amplitude of circadian clocks, with particular emphasis on the mammalian clock. We will discuss the potential of exploiting these small molecule modifiers in both basic and translational research.

Original languageEnglish (US)
Pages (from-to)2985-2998
Number of pages14
JournalCellular and Molecular Life Sciences
Issue number16
StatePublished - Aug 2013


  • Amplitude
  • Chronotherapy
  • Clock-associated diseases
  • Metabolites
  • Period
  • Phase
  • Synthetic compounds

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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