Small cell lung cancer 1973-1983: Early progress and recent obstacles

George Morstyn, Daniel C. Ihde, Allen S. Lichter, Paul A. Bunn, Desmond N. Carney, Eli Glatstein, John D. Minna

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


The recognition that the vast majority of patients with small cell lung cancer have distant metastatic disease at the time of diagnosis led to the use of systemic chemotherapy and consequent major improvements in survival in the early to mid-1970's. In the past five years, however, the pace of therapeutic advances has slowed. Recently evaluated treatment strategies, including more intensive induction chemotherapy, "late intensive' therapy of responding patients, alternation of chemotherapeutic regimens, integration of chest irradiation with drug therapy, large field irradiation, and reappraisal of the value of surgical resection, are discussed in this review. Advances in understanding of the cell biology of small cell lung cancer which may eventually lead to new forms of treatment are summarized.

Original languageEnglish (US)
Pages (from-to)515-539
Number of pages25
JournalInternational journal of radiation oncology, biology, physics
Issue number4
StatePublished - Apr 1984


  • Cell biology of small cell lung cancer
  • Chemotherapeutic agents
  • Chemotherapeutic strategy in small cell lung cancer, Thoracic irradiation
  • Cranial irradiation
  • Lung neoplasms, small cell
  • Wide field irradiation

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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