@article{ee5703aa80b845179b6fc2a05f5a0b00,
title = "Smad10 is required for formation of the frog nervous system",
abstract = "Before the nervous system establishes its complex array of cell types and connections, multipotent cells are instructed to adopt a neural fate and an anterior-posterior pattern is established. In this report, we show that Smad10, a member of the Smad family of intracellular transducers of TGFβ signaling, is required for formation of the nervous system. In addition, two types of molecules proposed as key to neural induction and patterning, bone morphogenetic protein (BMP) antagonists and fibroblast growth factor (FGF), require Smad10 for these activities. These data suggest that Smad10 may be a central mediator of the development of the frog nervous system.",
author = "LeSueur, {James A.} and Fortuno, {Edgardo S.} and McKay, {Ren{\'e}e M.} and Graff, {Jonathan M.}",
note = "Funding Information: We thank M. Henkemeyer, J. Jiang, L. Parada, T. Furukawa, J. Johnson, D. McKearin, E. Olson, members of the Center for Developmental Biology, and members of the Graff lab for support and comments. We also thank S. McKnight, J. Rutter, C. Hill, R. Harland, M. Cobb, Y. Sasai, C. Kintner, and E. Amaya for generously providing reagents and technical advice. R.M.M. is supported by NICHD (F32 HD08609-01). This work was supported by awards from the NICHD and the March of Dimes to J.M.G. J.M.G. is a Charles E. Culpeper Medical Scholar and receives support from the Rockefeller Brothers Fund. J.M.G. is an American Cancer Society Scholar and a Leukemia and Lymphoma Society Scholar. J.A.L. is a trainee of the DCMB NIH training grant. This work is dedicated to the memory of J.A.L.'s grandfather, A.C. Speirs.",
year = "2002",
doi = "10.1016/S1534-5807(02)00172-7",
language = "English (US)",
volume = "2",
pages = "771--783",
journal = "Developmental cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "6",
}