TY - JOUR
T1 - Slow-wave sleep and symptomatology in schizophrenia and related psychotic disorders
AU - Keshavan, Matcheri S.
AU - Miewald, Jean
AU - Haas, Gretchen
AU - Sweeney, John
AU - Ganguli, Rohan
AU - Reynolds, Charles F.
PY - 1995
Y1 - 1995
N2 - Deficits in slow-wave sleep (SWS), or delta sleep, are frequently seen in schizophrenia, but their relation with schizophrenic symptomatology remains unclear. We examined the association between visually scored and automated measures of SWS and positive and negative symptoms in a series of unmedicated patients with schizophrenia and related psychotic disorders. Total and average automated delta wave counts were significantly inversely associated with negative symptoms overall, and the psychomotor poverty syndrome in particular. Total delta counts were also inversely related to the disorganization syndrome. No relation was seen between reality distortion or the Brief Psychiatric Rating Scale (BPRS) positive symptoms and SWS. These findings support the view that SWS deficits may be related to negative symptoms of schizophrenia and may perhaps be mediated by impaired functioning of frontothalamic neural circuits.
AB - Deficits in slow-wave sleep (SWS), or delta sleep, are frequently seen in schizophrenia, but their relation with schizophrenic symptomatology remains unclear. We examined the association between visually scored and automated measures of SWS and positive and negative symptoms in a series of unmedicated patients with schizophrenia and related psychotic disorders. Total and average automated delta wave counts were significantly inversely associated with negative symptoms overall, and the psychomotor poverty syndrome in particular. Total delta counts were also inversely related to the disorganization syndrome. No relation was seen between reality distortion or the Brief Psychiatric Rating Scale (BPRS) positive symptoms and SWS. These findings support the view that SWS deficits may be related to negative symptoms of schizophrenia and may perhaps be mediated by impaired functioning of frontothalamic neural circuits.
UR - http://www.scopus.com/inward/record.url?scp=0029097358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029097358&partnerID=8YFLogxK
U2 - 10.1016/0022-3956(95)00023-X
DO - 10.1016/0022-3956(95)00023-X
M3 - Article
C2 - 8847657
AN - SCOPUS:0029097358
SN - 0022-3956
VL - 29
SP - 303
EP - 314
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 4
ER -