TY - JOUR
T1 - Sleeping sickness disrupts the sleep-regulating adenosine system
AU - Rijo-Ferreira, Filipa
AU - Bjorness, Theresa E.
AU - Cox, Kimberly H.
AU - Sonneborn, Alex
AU - Greene, Robert W.
AU - Takahashi, Joseph S.
N1 - Publisher Copyright:
Copyright © 2020 the authors
PY - 2020/11/25
Y1 - 2020/11/25
N2 - Patients with sleeping sickness, caused by the parasite Trypanosoma brucei, have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed the sleep architecture of male mice infected with T. brucei and found that infected mice had drastically altered sleep patterns. Interestingly, T. brucei-infected mice also had a reduced homeostatic sleep response to sleep deprivation, a response modulated by the adenosine system. We found that infected mice had a reduced electrophysiological response to an adenosine receptor antagonist and increased adenosine receptor gene expression. Although the mechanism by which T. brucei infection causes these changes remains to be determined, our findings suggest that the symptoms of sleeping sickness may be because of alterations in homeostatic adenosine signaling.
AB - Patients with sleeping sickness, caused by the parasite Trypanosoma brucei, have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed the sleep architecture of male mice infected with T. brucei and found that infected mice had drastically altered sleep patterns. Interestingly, T. brucei-infected mice also had a reduced homeostatic sleep response to sleep deprivation, a response modulated by the adenosine system. We found that infected mice had a reduced electrophysiological response to an adenosine receptor antagonist and increased adenosine receptor gene expression. Although the mechanism by which T. brucei infection causes these changes remains to be determined, our findings suggest that the symptoms of sleeping sickness may be because of alterations in homeostatic adenosine signaling.
KW - Adenosine
KW - Homeostasis
KW - Sleep
KW - Sleeping sickness
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U2 - 10.1523/JNEUROSCI.1046-20.2020
DO - 10.1523/JNEUROSCI.1046-20.2020
M3 - Article
C2 - 33097636
AN - SCOPUS:85096884129
SN - 0270-6474
VL - 40
SP - 9306
EP - 9316
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 48
ER -