Sleeping Sickness: A Tale of Two Clocks

Filipa Rijo-Ferreira, Joseph S. Takahashi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.

Original languageEnglish (US)
Article number525097
JournalFrontiers in Cellular and Infection Microbiology
StatePublished - Oct 2 2020


  • circadial rhythm disorders
  • circadian
  • infectious disease
  • parasite
  • sleep

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


Dive into the research topics of 'Sleeping Sickness: A Tale of Two Clocks'. Together they form a unique fingerprint.

Cite this