Skin Lesions Associated with Gastrointestinal and Liver Diseases

This chapter presents the cutaneous manifestations of gastrointestinal (GI) diseases with emphasis on epidemiology, pathophysiology, clinical manifestations, and treatment considerations. Muir-Torre syndrome (MTS) is a variant of Lynch syndrome characterized by the cooccurrence of visceral malignancies, sebaceous neoplasms of the skin, and multiple keratoacanthomas. Acanthosis nigricans (AN) present as hyperpigmented velvety or papillomatous plaques of the skin. AN occurs in acquired and inherited forms. Involvement of perioral or perianal mucosa in patients with Crohn's disease (CD) may be evident on dermatological examination. Reactive lesions associated with inflammatory bowel disease (IBD), such as erythema nodosum, apthous ulcers, and pyoderma gangrenosum are covered in the chapter. A number of medical conditions have been associated with palmar erythema (PE), including pregnancy, liver disease, thyroid disease, diabetes mellitus, and connective tissue diseases. Both acute and chronic diseases affecting the pancreas may lead to cutaneous manifestations. The chapter outlines mucocutaneous manifestations of nutritional deficiencies.