Sjögren's syndrome

Sadik A. Khuder, Ibtisam Al-Hashimi, Anand B. Mutgi

Research output: Chapter in Book/Report/Conference proceedingChapter


Sjögren's syndrome is a disease of the exocrine glands frequently defined as dry mouth and dry eyes. The exocrine system encompasses glands that are distributed throughout the body, and they produce variety of secretory products such as the digestive enzymes and bile, sweat, saliva, tears, cerumen, prostate and vaginal fluids, and the mucus secretions of the respiratory and gastrointestinal systems. Reduction and/or alteration in the exocrine secretions disrupt the normal physiology, shift the balance of the microbiota, and subject the body to variety of diseases. Although initial symptoms of Sjögren's syndrome may be subclinical and mild, Sjögren's syndrome is often associated with a significant number of serious and life-threatening comorbidities. This chapter reviews the prevalence and implications of the most frequently reported comorbidities in Sjögren's syndrome.

Original languageEnglish (US)
Title of host publicationComorbidity in Rheumatic Diseases
PublisherSpringer International Publishing
Number of pages18
ISBN (Electronic)9783319599632
ISBN (Print)9783319599625
StatePublished - Aug 24 2017


  • Autoimmune comorbidities of Sjögren's syndrome
  • Cardiovascular comorbidities of Sjögren's syndrome
  • Clinical manifestations of Sjögren's syndrome
  • Comorbidities of Sjögren's syndrome
  • Gastrointestinal comorbidities of Sjögren's syndrome
  • Neurological comorbidities of Sjögren's syndrome
  • Psychological comorbidities of Sjögren's syndrome
  • Pulmonary comorbidities of Sjögren's syndrome
  • Sjögren's syndrome
  • Vascular comorbidities of Sjögren's syndrome

ASJC Scopus subject areas

  • Medicine(all)


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