Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Cunqi Ye, Benjamin P. Tu

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.

Original languageEnglish (US)
Pages (from-to)626-637
Number of pages12
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Sep 2018


  • SAM
  • acetate
  • acetyl-CoA
  • epigenetics
  • histone acetylation
  • histone methylation

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism'. Together they form a unique fingerprint.

Cite this