Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Cunqi Ye; Benjamin P. Tu

doi:10.1016/j.tem.2018.06.002

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Cunqi Ye, Benjamin P. Tu

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.

Original language	English (US)
Pages (from-to)	626-637
Number of pages	12
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.tem.2018.06.002
State	Published - Sep 2018

Keywords

SAM
acetate
acetyl-CoA
epigenetics
histone acetylation
histone methylation

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2018.06.002

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title = "Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism",

abstract = "Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.",

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AU - Tu, Benjamin P.

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N2 - Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.

AB - Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.

KW - SAM

KW - acetate

KW - acetyl-CoA

KW - epigenetics

KW - histone acetylation

KW - histone methylation

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JO - Trends in Endocrinology and Metabolism

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Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Abstract

Keywords

ASJC Scopus subject areas

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