Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime

J. C. Morrison; J. N. Martin; P. G. Blake; P. R. Howard; D. L. Hemsell; P. G. Hemsell; B. J. Nobles; M. L. Heard; A. J. Fenton; R. M. Bernstein; A. S. Berkeley; K. S. Freedman; R. H. Brakemeier; C. V. Capen; A. G. McHaffey; C. Fouts-Johnson; E. P. King

Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime

J. C. Morrison, J. N. Martin, P. G. Blake, P. R. Howard, D. L. Hemsell, P. G. Hemsell, B. J. Nobles, M. L. Heard, A. J. Fenton, R. M. Bernstein, A. S. Berkeley, K. S. Freedman, R. H. Brakemeier, C. V. Capen, A. G. McHaffey, C. Fouts-Johnson, E. P. King

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Abstract

The efficacy of perioperative antimicrobial prophylaxis in preventing infection after vaginal hysterectomy has been demonstrated. In this study 260 patients undergoing vaginal hysterectomy were randomly assigned at five centers to receive 1 gm of cefamandole (N = 129) or cefotaxime (N = 131) immediately before operation. The two treatment groups were comparable. Febrile morbidity occurred in seven (5.4%) cefamandole patients and in 17 (13%) of those given cefotaxime (p = 0.04). In contrast, the number of patients who developed major pelvic infection was equal (cefamandole, 6; cefotaxime, 5). There was no significant difference in the concentration of either drug in the serum or tissues surveyed, and there was no correlation between infection and concentration of antibiotic in either group. The mean hospital stay and the mean total hospitalization charge did not differ significantly between the two groups. Both of these agents given as a single dose before vaginal hysterectomy are effective in reducing postoperative infections.

Original language	English (US)
Pages (from-to)	1198-1201
Number of pages	4
Journal	American Journal of Obstetrics and Gynecology
Volume	160
Issue number	5 I
State	Published - 1989

ASJC Scopus subject areas

Medicine(all)

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Morrison, J. C., Martin, J. N., Blake, P. G., Howard, P. R., Hemsell, D. L., Hemsell, P. G., Nobles, B. J., Heard, M. L., Fenton, A. J., Bernstein, R. M., Berkeley, A. S., Freedman, K. S., Brakemeier, R. H., Capen, C. V., McHaffey, A. G., Fouts-Johnson, C., & King, E. P. (1989). Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime. American Journal of Obstetrics and Gynecology, 160(5 I), 1198-1201.

Morrison, JC, Martin, JN, Blake, PG, Howard, PR, Hemsell, DL, Hemsell, PG, Nobles, BJ, Heard, ML, Fenton, AJ, Bernstein, RM, Berkeley, AS, Freedman, KS, Brakemeier, RH, Capen, CV, McHaffey, AG, Fouts-Johnson, C & King, EP 1989, 'Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime', American Journal of Obstetrics and Gynecology, vol. 160, no. 5 I, pp. 1198-1201.

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title = "Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime",

abstract = "The efficacy of perioperative antimicrobial prophylaxis in preventing infection after vaginal hysterectomy has been demonstrated. In this study 260 patients undergoing vaginal hysterectomy were randomly assigned at five centers to receive 1 gm of cefamandole (N = 129) or cefotaxime (N = 131) immediately before operation. The two treatment groups were comparable. Febrile morbidity occurred in seven (5.4%) cefamandole patients and in 17 (13%) of those given cefotaxime (p = 0.04). In contrast, the number of patients who developed major pelvic infection was equal (cefamandole, 6; cefotaxime, 5). There was no significant difference in the concentration of either drug in the serum or tissues surveyed, and there was no correlation between infection and concentration of antibiotic in either group. The mean hospital stay and the mean total hospitalization charge did not differ significantly between the two groups. Both of these agents given as a single dose before vaginal hysterectomy are effective in reducing postoperative infections.",

author = "Morrison, {J. C.} and Martin, {J. N.} and Blake, {P. G.} and Howard, {P. R.} and Hemsell, {D. L.} and Hemsell, {P. G.} and Nobles, {B. J.} and Heard, {M. L.} and Fenton, {A. J.} and Bernstein, {R. M.} and Berkeley, {A. S.} and Freedman, {K. S.} and Brakemeier, {R. H.} and Capen, {C. V.} and McHaffey, {A. G.} and C. Fouts-Johnson and King, {E. P.}",

year = "1989",

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AU - Morrison, J. C.

AU - Martin, J. N.

AU - Blake, P. G.

AU - Howard, P. R.

AU - Hemsell, D. L.

AU - Hemsell, P. G.

AU - Nobles, B. J.

AU - Heard, M. L.

AU - Fenton, A. J.

AU - Bernstein, R. M.

AU - Berkeley, A. S.

AU - Freedman, K. S.

AU - Brakemeier, R. H.

AU - Capen, C. V.

AU - McHaffey, A. G.

AU - Fouts-Johnson, C.

AU - King, E. P.

PY - 1989

Y1 - 1989

N2 - The efficacy of perioperative antimicrobial prophylaxis in preventing infection after vaginal hysterectomy has been demonstrated. In this study 260 patients undergoing vaginal hysterectomy were randomly assigned at five centers to receive 1 gm of cefamandole (N = 129) or cefotaxime (N = 131) immediately before operation. The two treatment groups were comparable. Febrile morbidity occurred in seven (5.4%) cefamandole patients and in 17 (13%) of those given cefotaxime (p = 0.04). In contrast, the number of patients who developed major pelvic infection was equal (cefamandole, 6; cefotaxime, 5). There was no significant difference in the concentration of either drug in the serum or tissues surveyed, and there was no correlation between infection and concentration of antibiotic in either group. The mean hospital stay and the mean total hospitalization charge did not differ significantly between the two groups. Both of these agents given as a single dose before vaginal hysterectomy are effective in reducing postoperative infections.

AB - The efficacy of perioperative antimicrobial prophylaxis in preventing infection after vaginal hysterectomy has been demonstrated. In this study 260 patients undergoing vaginal hysterectomy were randomly assigned at five centers to receive 1 gm of cefamandole (N = 129) or cefotaxime (N = 131) immediately before operation. The two treatment groups were comparable. Febrile morbidity occurred in seven (5.4%) cefamandole patients and in 17 (13%) of those given cefotaxime (p = 0.04). In contrast, the number of patients who developed major pelvic infection was equal (cefamandole, 6; cefotaxime, 5). There was no significant difference in the concentration of either drug in the serum or tissues surveyed, and there was no correlation between infection and concentration of antibiotic in either group. The mean hospital stay and the mean total hospitalization charge did not differ significantly between the two groups. Both of these agents given as a single dose before vaginal hysterectomy are effective in reducing postoperative infections.

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Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime

Abstract

ASJC Scopus subject areas

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