Signal control through Raf: In sickness and in health

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalCell Research
Issue number1
StatePublished - Jan 2012


  • ERK1/2
  • MAPK
  • Raf

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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