Signal control through Raf: In sickness and in health

Jihan K. Osborne; Elma Zaganjor; Melanie H. Cobb

doi:10.1038/cr.2011.193

Signal control through Raf: In sickness and in health

Jihan K. Osborne, Elma Zaganjor, Melanie H. Cobb

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

Original language	English (US)
Pages (from-to)	14-22
Number of pages	9
Journal	Cell Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/cr.2011.193
State	Published - Jan 2012

Keywords

ERK1/2
MAPK
Raf

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2011.193

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title = "Signal control through Raf: In sickness and in health",

abstract = "The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.",

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AB - The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

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Signal control through Raf: In sickness and in health

Abstract

Keywords

ASJC Scopus subject areas

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