Sialadenoma Papilliferum

Min Shu Hsieh, Justin A. Bishop, Julia Yu Fong Chang

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. SP most commonly occurs in the hard palate and in older adults. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Microscopically, SP shows an exophytic papillary epithelial proliferation and a contiguously endophytic ductal proliferation. Two distinct subtypes are identified: classic SP and oncocytic SP. Conservative surgical treatment seems to be adequate with a low recurrence. SOX10 immunohistochemistry and BRAF analysis may be useful in differential diagnosis.

Original languageEnglish (US)
Pages (from-to)43-51
Number of pages9
JournalSurgical Pathology Clinics
Issue number1
StatePublished - Mar 2021


  • BRAF V600E mutation
  • Classic
  • HRAS Q61R mutation
  • Oncocytic
  • Sialadenoma papilliferum

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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