@article{87d6894ee8694256aca4899da200e8ec,
title = "Short-term synaptic plasticity is altered in mice lacking synapsin I",
abstract = "Synapsin I, the major phosphoprotein of synaptic vesicles, is thought to play a central role in neurotransmitter release. Here we introduce a null mutation into the murine synapsin I gene by homologous recombination. Mice with no detectable synapsin I manifest no apparent changes in well-being or gross nervous system function. Thus, synapsin I is not essential for neurotransmitter release. Electrophysiology reveals that mice lacking synapsin I exhibit a selective increase in paired pulse facilitation, with no major alterations in other synaptic parameters such as long-term potentiation. In addition to potential redundant functions shared with other proteins, synapsin I in normal mice may function to limit increases in neurotransmitter release elicited by residual Ca2+ after an initial stimulus.",
author = "Rosahl, {Thomas W.} and Martin Geppert and Diane Spillane and Joachim Herz and Hammer, {Robert E} and Malenka, {Robert C.} and S{\"u}dhof, {Thomas C.}",
note = "Funding Information: Correspondence should be addressed to T. C. S. We thank Drs. M. S. Brown and J. L. Goldstein for continued support and advice, Dr. A. Bradley for the leukemia inhibitory factor-producing ST0 cells, and Dr. P. Soriano for his gift of the neomycin vector with the RNA polymerase II promoter. We are grateful to Ms. L. Lundquist, Ms. A. Roth, and Ms. I. Leznicki for excellent technical contributions. This study was supported by grants from the National Institutes of Health, the McKnight Foundation, and the National Alliance for Research on Schizophrenia and Depression (to Ft. C. M.); by the Perot Family Foundation (toT. C. S., R. E. H., and J. H.); bythe Lucille Markey Charitable Trust and the Syntex Scholar Program (to J. H.); by the Excellence in Education Fund (to R. E. H.) and the Keck Foundation; and by postdoctoral fellowships from the Deutsche Forschungsgemeinschaft (to T. W. R. and M. G.).",
year = "1993",
month = nov,
day = "19",
doi = "10.1016/0092-8674(93)90487-B",
language = "English (US)",
volume = "75",
pages = "661--670",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}