SHIP, TGF-β, and endotoxin tolerance

Bruce Beutler

doi:10.1016/j.immuni.2004.07.014

SHIP, TGF-β, and endotoxin tolerance

Bruce Beutler

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Research into the biology of endotoxin (aka lipopolysaccharide; LPS) began well over 100 years ago (Pfeiffer, 1892) and has had many unexpected turns. The phenomenon of endotoxin tolerance was among these and has engendered immense curiosity over the years. Sly and colleagues (this issue of Immunity) have taken an important step toward understanding the phenomenon of endotoxin tolerance and have enhanced our comprehension of LPS signaling as a whole by demonstrating that the cytosolic phosphatase SHIP is required to permit the development of an LPS-refractory state in macrophages and mice.

Original language	English (US)
Pages (from-to)	134-135
Number of pages	2
Journal	Immunity
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2004.07.014
State	Published - Aug 2004

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2004.07.014

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SHIP, TGF-β, and endotoxin tolerance

Abstract

ASJC Scopus subject areas

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