Abstract
The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.
Original language | English (US) |
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Pages (from-to) | 219-223 |
Number of pages | 5 |
Journal | Molecular and Cellular Endocrinology |
Volume | 336 |
Issue number | 1-2 |
DOIs | |
State | Published - Apr 10 2011 |
Keywords
- Arcuate nucleus of the hypothalamus (ARH)
- Diet-induced obesity
- Dorsomedial hypothalamic nucleus (DMH)
- Energy homeostasis
- Steroidogenic factor 1 (SF-1)
- Ventral medial nucleus of the hypothalamus (VMH)
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology