Severe intraventricular hemorrhage and withdrawal of support in preterm infants

J. W. Sheehan; M. Pritchard; R. J. Heyne; L. S. Brown; M. A. Jaleel; W. D. Engle; P. J. Burchfield; L. P. Brion

doi:10.1038/jp.2016.233

Severe intraventricular hemorrhage and withdrawal of support in preterm infants

J. W. Sheehan, M. Pritchard, R. J. Heyne, L. S. Brown, M. A. Jaleel, W. D. Engle, P. J. Burchfield, L. P. Brion

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objective: The objective of the study was to determine whether withdrawal of support in severe 'intraventricular hemorrhage' (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan. Study design: Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks' gestation in 1993 to 2013. Results: Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three. Conclusion: Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.

Original language	English (US)
Pages (from-to)	441-447
Number of pages	7
Journal	Journal of Perinatology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1038/jp.2016.233
State	Published - Apr 1 2017

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/jp.2016.233

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abstract = "Objective: The objective of the study was to determine whether withdrawal of support in severe 'intraventricular hemorrhage' (IVH), that is, IVH grade 3 and periventricular hemorrhagic infarction (PVHI), has decreased after publication of studies that show improved prognosis and to examine cranial ultrasonograms, including PVHI territories defined by Bassan. Study design: Retrospective cohort of preterm infants from 23 0/7 to 28 6/7 weeks' gestation in 1993 to 2013. Results: Among the 1755 infants, 1494 had no bleed, germinal matrix hemorrhage (GMH) or IVH grade 2, 137 had grade 3 IVH and 124 had PVHI. The odds of withdrawal of support, adjusted for severity of GMH-IVH and baseline variables, did not decrease after publications showing better prognosis. Among 82 patients who died with PVHI, 76 had life support withdrawn, including 34 without another contributing cause of death. The median number of PVHI territories involved was three. Conclusion: Withdrawal of support adjusted for severity of GMH-IVH did not significantly change after publications showing better prognosis.",

author = "Sheehan, {J. W.} and M. Pritchard and Heyne, {R. J.} and Brown, {L. S.} and Jaleel, {M. A.} and Engle, {W. D.} and Burchfield, {P. J.} and Brion, {L. P.}",

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AU - Heyne, R. J.

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AU - Jaleel, M. A.

AU - Engle, W. D.

AU - Burchfield, P. J.

AU - Brion, L. P.

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Severe intraventricular hemorrhage and withdrawal of support in preterm infants

Abstract

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