Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

Bibhuti B. Das; Lawrence Shoemaker; Edward Kim; Christopher E. Mascio; Erle H. Austin

doi:10.1111/j.1399-3046.2011.01557.x

Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

Bibhuti B. Das, Lawrence Shoemaker, Edward Kim, Christopher E. Mascio, Erle H. Austin

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

Original language	English (US)
Pages (from-to)	E162-E166
Journal	Pediatric Transplantation
Volume	16
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-3046.2011.01557.x
State	Published - Aug 2012

Keywords

pediatric cardiac transplantation
sarcoidosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/j.1399-3046.2011.01557.x

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abstract = "We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.",

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AU - Austin, Erle H.

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AB - We report a unique case of severe calcification of the aorta, bilateral coronary ostial stenoses and calcification of the mitral valve and left ventricle due to sarcoidosis. The patient underwent neonatal orthotopic heart transplantation secondary to hypoplastic left heart syndrome and developed hypercalcemia with other features of sarcoidosis at 10 yr of age. The mechanism for severe extra-renal calcification localized to the allograft is poorly understood, but may involve discordant local immune modulation and/or calcification-regulation between graft and host tissues.

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Severe calcification of the aorta (porcelain aorta) associated with sarcoidosis in a pediatric heart transplant recipient

Abstract

Keywords

ASJC Scopus subject areas

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