TY - JOUR
T1 - Severe Autoimmune Hemolytic Anemia in an Infant Caused by Warm-reactive IGM and IGA Autoantibodies
T2 - A Case Report and Review of the Literature
AU - Branstetter, Cristyn N.
AU - Hankins, Jane S.
AU - Moreau, Dawn
AU - Nottage, Kerri A.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Warm-reactive IgM autoimmune hemolytic anemia is uncommon and carries a poor prognosis in adults. There have been rare reports in children, generally associated with an underlying immunologic deficiency, and outcomes are quite variable. Warm IgM in combination with other antibodies has not been reported in children. We report the first case of severe, steroid-responsive autoimmune hemolytic anemia caused by both warm-reactive IgM and IgA autoantibodies in an otherwise healthy 3-month-old.
AB - Warm-reactive IgM autoimmune hemolytic anemia is uncommon and carries a poor prognosis in adults. There have been rare reports in children, generally associated with an underlying immunologic deficiency, and outcomes are quite variable. Warm IgM in combination with other antibodies has not been reported in children. We report the first case of severe, steroid-responsive autoimmune hemolytic anemia caused by both warm-reactive IgM and IgA autoantibodies in an otherwise healthy 3-month-old.
KW - autoimmune hemolytic anemia
KW - IgA autoantibody
KW - warm IgM autoantibody
UR - http://www.scopus.com/inward/record.url?scp=84938594895&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938594895&partnerID=8YFLogxK
U2 - 10.1097/MPH.0000000000000359
DO - 10.1097/MPH.0000000000000359
M3 - Article
C2 - 26181418
AN - SCOPUS:84938594895
SN - 1077-4114
VL - 37
SP - 468
EP - 471
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 6
ER -