Serum immunoglobulin levels in newborn infants. III. Some preliminary observations from a survey of cord blood levels in 2,600 infants

Janet B. Hardy; George H. McCracken; E. David Mellits; Mary R. Gilkeson; John L. Sever

doi:10.1016/s0022-3476(69)80377-x

Serum immunoglobulin levels in newborn infants. III. Some preliminary observations from a survey of cord blood levels in 2,600 infants

Janet B. Hardy, George H. McCracken, E. David Mellits, Mary R. Gilkeson, John L. Sever

Research output: Contribution to journal › Article › peer-review

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Abstract

Cord serum immunoglobulin G and M levels and their relationship to race, sex, birth weight, and clinical status are examined. The levels of both immunoglobulins are not related to sex. Negro infants have higher IgG and lower IgM levels than Caucasians. IgG levels and birth weight are associated, smaller infants having lower levels. The previously reported relationship between high levels of IgM and congenital infection is confirmed. In addition, a significant relationship between very low levels and adverse fetal outcome is demonstrated by neurologic abnormalities, severe congenital malformations, and perinatal deaths.

Original language	English (US)
Pages (from-to)	1211-1223
Number of pages	13
Journal	The Journal of pediatrics
Volume	75
Issue number	6 PART 2
DOIs	https://doi.org/10.1016/s0022-3476(69)80377-x
State	Published - Dec 1969

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Serum immunoglobulin levels in newborn infants. III. Some preliminary observations from a survey of cord blood levels in 2,600 infants",

abstract = "Cord serum immunoglobulin G and M levels and their relationship to race, sex, birth weight, and clinical status are examined. The levels of both immunoglobulins are not related to sex. Negro infants have higher IgG and lower IgM levels than Caucasians. IgG levels and birth weight are associated, smaller infants having lower levels. The previously reported relationship between high levels of IgM and congenital infection is confirmed. In addition, a significant relationship between very low levels and adverse fetal outcome is demonstrated by neurologic abnormalities, severe congenital malformations, and perinatal deaths.",

author = "Hardy, {Janet B.} and McCracken, {George H.} and Mellits, {E. David} and Gilkeson, {Mary R.} and Sever, {John L.}",

note = "Funding Information: Supported in part by the National Institute of Health Grant No. 02371 and National Institutes of Health Contract Nos. PH 43 68 12 and PH 43 68 710.",

year = "1969",

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doi = "10.1016/s0022-3476(69)80377-x",

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T1 - Serum immunoglobulin levels in newborn infants. III. Some preliminary observations from a survey of cord blood levels in 2,600 infants

AU - Hardy, Janet B.

AU - McCracken, George H.

AU - Mellits, E. David

AU - Gilkeson, Mary R.

AU - Sever, John L.

N1 - Funding Information: Supported in part by the National Institute of Health Grant No. 02371 and National Institutes of Health Contract Nos. PH 43 68 12 and PH 43 68 710.

PY - 1969/12

Y1 - 1969/12

N2 - Cord serum immunoglobulin G and M levels and their relationship to race, sex, birth weight, and clinical status are examined. The levels of both immunoglobulins are not related to sex. Negro infants have higher IgG and lower IgM levels than Caucasians. IgG levels and birth weight are associated, smaller infants having lower levels. The previously reported relationship between high levels of IgM and congenital infection is confirmed. In addition, a significant relationship between very low levels and adverse fetal outcome is demonstrated by neurologic abnormalities, severe congenital malformations, and perinatal deaths.

AB - Cord serum immunoglobulin G and M levels and their relationship to race, sex, birth weight, and clinical status are examined. The levels of both immunoglobulins are not related to sex. Negro infants have higher IgG and lower IgM levels than Caucasians. IgG levels and birth weight are associated, smaller infants having lower levels. The previously reported relationship between high levels of IgM and congenital infection is confirmed. In addition, a significant relationship between very low levels and adverse fetal outcome is demonstrated by neurologic abnormalities, severe congenital malformations, and perinatal deaths.

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Serum immunoglobulin levels in newborn infants. III. Some preliminary observations from a survey of cord blood levels in 2,600 infants

Abstract

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