TY - JOUR
T1 - Serum Growth Differentiation Factor 15 Levels Are Associated With Depression After Ischemic Stroke
AU - Zang, Yuhan
AU - Zhu, Zhengbao
AU - Xie, Yi
AU - Liu, Zhen
AU - Yin, Jieyun
AU - Yang, Pinni
AU - Zhang, Kaixin
AU - Bu, Xiaoqing
AU - Ailiwang,
AU - Chen, Jing
AU - Zhang, Yonghong
AU - He, Jiang
N1 - Publisher Copyright:
© 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2022/1/4
Y1 - 2022/1/4
N2 - BACKGROUND: The effect of serum growth differentiation factor 15 (GDF-15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF-15 and PSD among patients with ischemic stroke. METHODS AND RESULTS: This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF-15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate-adjusted odds ratio of PSD associated with the highest tertile of serum GDF-15 was 2.92 (95% CI, 1.36–6.27) compared with the lowest tertile. Each SD increase in log-transformed GDF-15 was associated with a 42% (95% CI, 2%–97%) increased risk of PSD, and a linear association between serum GDF-15 and the risk of PSD was observed (P for linearity=0.006). CONCLUSIONS: Elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
AB - BACKGROUND: The effect of serum growth differentiation factor 15 (GDF-15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF-15 and PSD among patients with ischemic stroke. METHODS AND RESULTS: This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF-15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate-adjusted odds ratio of PSD associated with the highest tertile of serum GDF-15 was 2.92 (95% CI, 1.36–6.27) compared with the lowest tertile. Each SD increase in log-transformed GDF-15 was associated with a 42% (95% CI, 2%–97%) increased risk of PSD, and a linear association between serum GDF-15 and the risk of PSD was observed (P for linearity=0.006). CONCLUSIONS: Elevated serum GDF-15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF-15 may be a valuable prognostic biomarker for PSD.
KW - Acute ischemic stroke
KW - growth differentiation factor 15
KW - Hamilton rating scale for depression
KW - poststroke depression
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U2 - 10.1161/JAHA.121.022607
DO - 10.1161/JAHA.121.022607
M3 - Article
C2 - 34970912
AN - SCOPUS:85123392697
SN - 2047-9980
VL - 11
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 1
M1 - e022607
ER -