Seroepidemiology of strongyloidiasis in a thai village

Richard W. Douce, Arthur E. Brown, Chirasak Khamboonruang, Peter D. Walzer, Robert M. Genta

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23 Scopus citations


Strongyloidiasis is a potentially fatal disease for which existing methods of diagnosis lack sensitivity. A recently developed ELISA for IgG antibodies against the infective larval stage was used to screen a leprosy resettlement village in an area endemic for strongyloidiasis. The results of the ELISA were compared with the results of stool examination for 177 villagers. Eleven per cent of the village had S. stercoralis present on stool examination and 45% had antibodies detected by ELISA. Eighteen of 21 (85%) villagers with S. stercoralis infection proven by stool examination had positive ELISA values. No cross reactivity with intraluminal parasites was present. Linear correlation between per cent eosinophils and the ELISA revealed a correlation coefficient of 0.402 (P < 0.001). Forty-two days after sucessful treatment in 14 villagers, the IgG antibody levels had decreased (P < 0.001). Leprosy did not affect the sensitivity of the assay. These results suggest that ELISA is a simple, sensitive and specific method for surveying exposure to S. stercoralis in an endemic area.

Original languageEnglish (US)
Pages (from-to)1343-1348
Number of pages6
JournalInternational Journal for Parasitology
Issue number7
StatePublished - Oct 1987


  • South East Asia
  • Strongyloides stercoralis
  • epidemiology
  • immunodiagnosis
  • serology
  • strongyloidiasis

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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