Serine metabolism: Some tumors take the road less traveled

Research output: Contribution to journalShort surveypeer-review

74 Scopus citations


Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

Original languageEnglish (US)
Pages (from-to)285-286
Number of pages2
JournalCell Metabolism
Issue number3
StatePublished - Sep 7 2011

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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