Serine metabolism: Some tumors take the road less traveled

Ralph J. Deberardinis

doi:10.1016/j.cmet.2011.08.004

Serine metabolism: Some tumors take the road less traveled

Ralph J. Deberardinis

Research output: Contribution to journal › Short survey › peer-review

84 Scopus citations

Abstract

Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

Original language	English (US)
Pages (from-to)	285-286
Number of pages	2
Journal	Cell Metabolism
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2011.08.004
State	Published - Sep 7 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2011.08.004

Cite this

@article{62e8f16dbd3941f098c66e9385f76641,

title = "Serine metabolism: Some tumors take the road less traveled",

abstract = "Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.",

author = "Deberardinis, {Ralph J.}",

year = "2011",

month = sep,

day = "7",

doi = "10.1016/j.cmet.2011.08.004",

language = "English (US)",

volume = "14",

pages = "285--286",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Serine metabolism

T2 - Some tumors take the road less traveled

AU - Deberardinis, Ralph J.

PY - 2011/9/7

Y1 - 2011/9/7

N2 - Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

AB - Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

UR - http://www.scopus.com/inward/record.url?scp=80052775587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052775587&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2011.08.004

DO - 10.1016/j.cmet.2011.08.004

M3 - Short survey

C2 - 21907134

AN - SCOPUS:80052775587

SN - 1550-4131

VL - 14

SP - 285

EP - 286

JO - Cell Metabolism

JF - Cell Metabolism

IS - 3

ER -

Serine metabolism: Some tumors take the road less traveled

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this