Sequential kidney–liver transplantation from the same living donor for lecithin cholesterol acyl transferase deficiency

Sarwat B. Ahmad, Michael Miller, Steven Hanish, Stephen T. Bartlett, William Hutson, Rolf N. Barth, John C. LaMattina

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Lecithin cholesterol acyl transferase (LCAT) deficiency is a rare autosomal recessive disorder of lipoprotein metabolism that results in end-stage renal disease (ESRD) necessitating transplantation. As LCAT is produced in the liver, combined kidney and liver transplantation was proposed to cure the clinical syndrome of LCAT deficiency. Methods: A 29-year-old male with ESRD secondary to LCAT deficiency underwent a sequential kidney–liver transplantation from the same living donor (LD). One year following the kidney transplant, auxiliary partial orthotopic liver transplant (APOLT) of a left lateral segment from the same donor was performed. Results: At 5 years follow-up, there have been no major complications, readmissions, or rejection episodes. Serum lipid abnormalities recurred within the first year, but liver and kidney allograft function remains intact. Conclusion: Few cases of sequential transplantation from the same LD have been performed in adults. This is the first APOLT and multi-organ transplant performed for LCAT deficiency. Sequential organ transplant from the same LD for ESRD secondary to a metabolic disorder of the liver is feasible in adults and should be further investigated.

Original languageEnglish (US)
Pages (from-to)1370-1374
Number of pages5
JournalClinical Transplantation
Issue number10
StatePublished - Oct 1 2016
Externally publishedYes


  • auxiliary liver transplantation
  • kidney transplantation
  • liver transplantation
  • living donor transplantation
  • sequential organ transplant

ASJC Scopus subject areas

  • Transplantation


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