Background: Mechanisms for sterol- and geranylgeraniol-induced dislocation of reductase from ER membranes into cytosol for degradation are unclear. Results: VCP/p97 mediates extraction of reductase across ER membranes, whereas the proteasome 19 S regulatory particle (RP) dislodges extracted reductase into cytosol. Conclusion: VCP/p97 and proteasome 19 S RP mediate sequential steps in reductase degradation. Significance: These results define a new step in the reductase degradative pathway.
|Original language||English (US)|
|Number of pages||14|
|Journal||Journal of Biological Chemistry|
|State||Published - Jul 4 2014|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology