Septins Set the Stage for Orai1 to Bind STIM1 at ER-PM Junctions

Jen Liou, Tobias Meyer

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


The endoplasmic reticulum (ER) Ca2+ sensor STIM1 recruits and activates the plasma membrane (PM) Ca2+ channel Orai1 at ER-PM junctions for store-operated Ca2+ entry (SOCE). Reporting in Nature, Sharma etal. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalDevelopmental cell
Issue number2
StatePublished - Jul 29 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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