Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography

Chulhong Kim, Kwang Hyun Song, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We apply ultrasound-modulated optical tomography (UOT) to image ex-vivo methylene-blue-dyed sentinel lymph nodes embedded in 3.2-cm-thick chicken breast tissues. The UOT system is implemented for the first time using ring-shaped light illumination, intense acoustic bursts, and charge-coupled device (CCD) camera-based speckle contrast detection. Since the system is noninvasive, nonionizing, portable, relatively cost effective, and easy to combine with photoacoustic imaging and single element ultrasonic pulse-echo imaging, UOT can potentially be a good imaging modality for the detection of sentinel lymph nodes in breast cancer staging in vivo.

Original languageEnglish (US)
Article number020507
JournalJournal of biomedical optics
Issue number2
StatePublished - 2008


  • acoustic bursts
  • axillary lymph node dissection
  • breast cancer
  • sentinel lymph node biopsy
  • speckle contrast
  • ultrasound-modulated optical tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering


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